β-Adrenergic mechanisms modulate central nervous system effects of prolactin on milk ejection

Morales, Teresa; Shapiro, Edna; Mena, Flavio

doi:10.1016/s0031-9384(01)00560-1

Cited by 3 publications

(14 citation statements)

References 41 publications

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“…The sympathetic nervous system plays the most important function in the process of milk ejection (Lukasova et al., ; Eriksson et al., ; Aceves et al., ; Morales et al., ,b; Wellnitz and Bruckmaier, ; Marina et al., ). To date, the sympathetic innervation of the mammary gland was characterized in women (Eriksson et al., ) and different animal species, such as rat (Eriksson et al., ; Morales et al., ), goat (Linzell, ,b; Lukas et al., ; Lukasova et al., ), sheep (Linzell, ,b; Ivanov et al., ), cat (Linzell, ), rabbit (Hebb and Linzell, ; Mena et al., ), cow (Linzell, ; Hebb and Linzell, ; Cowie, ; Maśliński et al., ; Michel, ), dog (Pinho and Gulbenkian, ) and pig (Franke‐Radowiecka et al., ).…”

Section: Introductionmentioning

confidence: 99%

“…To date, the sympathetic innervation of the mammary gland was characterized in women (Eriksson et al., ) and different animal species, such as rat (Eriksson et al., ; Morales et al., ), goat (Linzell, ,b; Lukas et al., ; Lukasova et al., ), sheep (Linzell, ,b; Ivanov et al., ), cat (Linzell, ), rabbit (Hebb and Linzell, ; Mena et al., ), cow (Linzell, ; Hebb and Linzell, ; Cowie, ; Maśliński et al., ; Michel, ), dog (Pinho and Gulbenkian, ) and pig (Franke‐Radowiecka et al., ). It was found that the sympathetic nervous system is involved in the regulation of local blood flow and effect on inhibition of the milk ejection (Mena et al., ; Eriksson et al., ; Morales et al., ,b; Wellnitz and Bruckmaier, ; Marina et al., ). Emerging evidence suggests that there are two mechanisms that are responsible for the inhibition of the secretion of milk, the central and peripheral mechanism (Morales et al., ,b; Wellnitz and Bruckmaier, ).…”

Section: Introductionmentioning

confidence: 99%

“…It was found that the sympathetic nervous system is involved in the regulation of local blood flow and effect on inhibition of the milk ejection (Mena et al., ; Eriksson et al., ; Morales et al., ,b; Wellnitz and Bruckmaier, ; Marina et al., ). Emerging evidence suggests that there are two mechanisms that are responsible for the inhibition of the secretion of milk, the central and peripheral mechanism (Morales et al., ,b; Wellnitz and Bruckmaier, ).…”

Section: Introductionmentioning

confidence: 99%

“…Catecholamines circulating in the blood cause the inhibition of the oxytocin releasing from the hypothalamus (Mena et al., ; Morales et al., ,b; Wellnitz and Bruckmaier, ). Catecholamines also bind to α ‐adrenergic receptors on myoepithelial cells which surround lactiferous ducts, or occur in the nipple, and cause that relaxation (Mena et al., ; Morales et al., ,b; Wellnitz and Bruckmaier, ).…”

Section: Introductionmentioning

confidence: 99%

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Immunohistochemical Characterization of Sympathetic Chain Ganglia (SChG) Neurons Supplying the Porcine mammary Gland

Franke-Radowiecka

Wąsowicz

Klimczuk

et al. 2015

Anat Histol Embryol

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The aim of this study was to investigate the chemical coding of mammary gland-projecting SChG neurons using double-labelling immunohistochemistry. Earlier observation showed that after injection of the retrograde tracer fast blue (FB) into the second, right thoracic mamma, FB+ mammary gland-projecting neurons were found in Th1-3, Th9-14 and L1-4 right SChG. The greatest number of FB+ nerve cell bodies was observed in Th10 (approx. 843) and Th11 (approx. 567). Neurons projecting to the last right abdominal mamma were found in L1-4 SChG. The greatest number of FB+ neurons was observed in L2 (approx. 1200). Immunohistochemistry revealed that the vast majority of FB+ mammary-projecting neurons contained immunoreactivities to TH (96.97%) and/or DßH (95.92%). Many TH/DßH-positive neurons stained for SOM (41.5%) or NPY (33.2%), and less numerous nerve cells expressed VIP (16.9%). This observation strongly corresponds to the results of previous studies concerning the immunohistochemical characterization of nerve fibres supplying the porcine mammary gland.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Immunohistochemical Characterization of Sympathetic Chain Ganglia (SChG) Neurons Supplying the Porcine mammary Gland

Franke-Radowiecka

Wąsowicz

Klimczuk

et al. 2015

Anat Histol Embryol

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“…We showed previously (Morales et al, 2001) that intrathecal injection of PRL in the spinal cord promoted the sympathetic inhibition of milk ejection in lactating rats, and that prolactin variants in CM from the central and peripheral regions of the anterior pituitary from lactating, but not from male rats promoted the in vitro release of PRL from pituitary glands of male rats in a dose-dependent manner (Huerta-Ocampo et al, 2007;Mena et al, 2010).…”

Section: Introductionmentioning

confidence: 94%

Autocrine and Paracrine Regulation of Prolactin Secretion by Prolactin Variants and by Hypothalamic Hormones

Mena¹,

Navarro²,

Castilla³

2013

Prolactin

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The nerve supply of the mammary gland

Franke-Radowiecka¹

2021

Medycyna Weterynaryjna

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Proper development and functioning of the mammary gland depends not only on hormones, but also on the nervous system. The aim of this paper was to summarize the existing knowledge on the innervation of the mammary gland in various mammalian species, including domestic animals. In general, the pattern of innervation of this gland is similar in all studied species, i.e. large farm animals, rodents, dogs and beavers, as well as humans. Using the pan-neuronal marker of neural structures PGP-9.5, it was found that the mammary gland is well supplied with nerve fibres. Very rich innervation was discovered in the nipple, and less numerous nerve endings were found in the parenchyma. Nerve fibres supply the skin, especially the nipple, and many nerve terminals are associated with blood vessels and smooth muscles throughout the organ. Immunohistochemical investigations have made it possible to distinguish two major subpopulations of nerve fibres supplying the mammary gland. One of them consists of putative sensory fibres expressing CGRP, SP, GAL and/or PACAP, and the other is presumably composed of adrenergic axons containing TH, DBH, SOM and/or VIP. Studies on the sources of innervation of the mammary gland have confirmed assumptions about the nature of the nerve fibres and have revealed that they derive from the spinal ganglia (DRG) and sympathetic trunk ganglia (SChG). In the rat, mammary gland-projecting (MGP) neurons were also found in the nodose ganglion. So far, the rat and the pig have been tested most comprehensively for the sources of the mammary gland innervation. The MGP sensory neurons were observed ipsilaterally in several consecutive DRG, suggesting that the same neurons supply several successive glands. In the case of the SChG, it was found that MGP neurons are located, among others, in the L1-L4 ganglia, which constitute a specific „mammary gland nerve centre”. Previous studies on the sources of nerve supply to female reproductive organs have revealed that the SChG L1-L4 ganglia also contain nerve cells that project to the ovary, fallopian tube and uterus. Some clinical implications of the mammary gland innervation are also discussed.

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β-Adrenergic mechanisms modulate central nervous system effects of prolactin on milk ejection

Cited by 3 publications

References 41 publications

Immunohistochemical Characterization of Sympathetic Chain Ganglia (SChG) Neurons Supplying the Porcine mammary Gland

Immunohistochemical Characterization of Sympathetic Chain Ganglia (SChG) Neurons Supplying the Porcine mammary Gland

Autocrine and Paracrine Regulation of Prolactin Secretion by Prolactin Variants and by Hypothalamic Hormones

The nerve supply of the mammary gland

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