β-3AR W64R Polymorphism and 30-Minute Post-Challenge Plasma Glucose Levels in Obese Children

Abstract

Objective:In this study, we aimed to investigate the association of W64R polymorphism of the β3-adrenergic receptor gene (β-3AR) with childhood obesity and related pathologies.Methods:β-3AR gene W64R genotyping was carried out in 251 children aged 6-18 years. Of these subjects, 130 were obese (62 boys) and 121 were normal-weight (53 boys). In the obese group, fasting lipids, glucose and insulin levels were measured. Oral glucose tolerance test (OGTT) was performed in 75 of the obese patients.Results:The frequency of W64R genotype was similar in obese and non-obese children. In obese children, relative body mass index, waist-to-hip ratio, serum lipid, glucose and insulin levels, as well as homeostasis model assessment of insulin resistance (HOMA-IR) scores were not different between Arg allele carriers (W64R and R64R) and noncarriers (W64W). In 75 obese children, OGTT results showed that Arg allele carriers had significantly higher 30-minute glucose levels (p=0.027).Conclusion:W64R polymorphism of the β-3AR gene is not associated with obesity and waist-to-hip ratio in Turkish children. Although there were no relationships between the genotypes and lipid, glucose/insulin levels or HOMA-IR, the presence of W64R variant seemed to have an unfavorable influence on early glucose excursion after glucose loading.

The Role of Active Video-Accompanied Exercises in Improvement of the Obese State in Children: A Prospective Study from Turkey

“…Obesity is a result of an imbalance between nutrient intake and energy expenditure (1). Due to the influence of technology and ever changing social structure, people now spend increasing amounts of their time in front of the television or computer.…”

TheADRB3rs4994 polymorphism increases risk of childhood and adolescent overweight/obesity for East Asia’s population: an evidence-based meta-analysis

“…There is still uncertainty regarding the genetic impact of the ADRB3 rs4994 polymorphism on the risk of childhood and adolescent overweight/obesity despite previous case-control studies [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32]. Our systematic literature review and meta-analysis identified statistical significance under allele model, heterozygote model, and dominant model, which suggest that the C allele of this polymorphism could be a risk factor.…”

“…Of the 239 individual publications initially identified, 16 unique studies [14][15][16][17][18][19][20][21][22][23][24][25][26][27]29,30] involving 5,147 overweight/obese cases and 7,350 non-obese controls were ultimately included for further synthetic analyses ( Figure 1). Totally, 69.9% of the included subjects came from East Asia.…”

“…To date, many epidemiological assessments were completed to quantitatively determine the association between the ADRB3 rs4994 polymorphism and risk of childhood and adolescent overweight/obesity. However, the scattered reports remain inconclusive and did not reach a consensus [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32]. These studies were plagued by multiple methodological shortcomings, including inadequate statistical power caused by a relatively small sample size, high potential risk of sampling bias, and inconsistent analysis strategies.…”

Association Between Trp64arg Polymorphism of the β3 adrenoreceptor Gene and Female Sex in Obese Turkish Children and Adolescents

“…However, studies on this association have reported contradictory results. Other researchers have reported that ADRB3 polymorphism exhibits no effect on obesity, type 2 diabetes [21222324], or energy expenditure in obese post-menopausal women [25].…”