“…The last decade has supplemented this list with two new families: αB [ 99 ] and αO-conotoxins [ 100 ] (see Figure 2 ); however, these families are represented by one or only a few peptides, which, as a rule, have not received further scientific development. As an exception, we can mention the discovery of a new αS-conotoxin, GVIIIB, which was a highly selective inhibitor of α9α10 nAChR [ 101 ], αM-conotoxin MIIIJ, which, like ψ-conotoxins, belongs to the M-superfamily and also blocks muscle nAChR [ 102 ], αO-conotoxin GeXIVA [ 100 ], with good prospects for medical use (see below) and several αD-conotoxins. Of the two isolated dimeric αD-conotoxins, GeXXA [ 103 ] ( Figure 3 ) and PiXXA [ 104 ], the first was shown to be a non-selective blocker of both neuronal and muscle receptor subtypes, while for the second, inhibitory activity was revealed only towards human α7 nAChR (IC 50 6.2 µM).…”