α1 Isoenzyme of alkaline phosphatases clinical importance and value for the detection of liver metastases

Viot, M.; Thyss, A.; Schneider, M.; Viot, G.; Ramaioli, A.; Cambon, P; Lalanne, C.M.

doi:10.1002/1097-0142(19830701)52:1<140::aid-cncr2820520125>3.0.co;2-7

Cited by 17 publications

(2 citation statements)

References 12 publications

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“…Furthermore, there is evidence that analysis of serumderived tumor-specific isoforms of alkaline phosphatase may increase the predictive accuracy of this marker. 35,36 Apart from CEA, no other blood-derived variable has been used in prognostic scoring in CRCLM, to our knowledge. We found that determination of serum alkaline phosphatase and albumin provides significant independent information about prognosis in all patients referred for surgery and in patients who underwent liver resection.…”

Section: Validation Of the Prognostic Scoring Systemmentioning

confidence: 99%

Prognostic Scoring in Colorectal Cancer Liver Metastases

Schindl

Wigmore²,

Currie³

et al. 2005

Arch Surg

118

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Hypothesis: A prognostic scoring system for colorectal cancer liver metastases that is derived from unselected patients referred for hepatic resection would improve the applicability and increase the accuracy of prognostication. Design: Retrospective analysis of prospectively documented data; validation against an unrelated cohort from another institution. The median follow-up was 16.4 months (95% confidence interval, 15.0-17.8 months) (original cohort). Setting: Two tertiary referral centers at unrelated university hospitals. Patients: Independent prognosticators of survival were derived from 337 patients with colorectal cancer liver metastases referred for consideration of liver resection, and prognostic scores were calculated in 269 patients (79.8%) (original cohort). Calculation of prognostic scores was also applied to 193 patients referred and treated in an unrelated institution (validation cohort). Main Outcome Measures: Kaplan-Meier survival curve analysis (log-rank test) between different prognostic groups in the original and the validation cohorts. Results: Independent prognosticators of survival were Dukes stage, number of metastases, and serum concentrations of carcinoembryonic antigen, alkaline phosphatase, and albumin. Significant differences were found in cumulative overall survival between patients assigned to good, moderate, and poor prognoses in the original and validation cohorts (PϽ.05). Liver resection improved survival in all prognostic groups. However, no patient with poor prognosis and only 19.7% (13 of 66) of patients with moderate prognosis survived 5 years, compared with 62.5% (10 of 16) of patients with good prognosis (PϽ.001). Conclusions: This prognostic scoring system is derived from and can be applied to patients with colorectal cancer liver metastases at the time of referral for consideration of surgery. Patients with poor prognosis have no long-term benefit from curative liver resection and should therefore be considered for combined multimodal treatment.

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Section: Validation Of the Prognostic Scoring Systemmentioning

confidence: 99%

Prognostic Scoring in Colorectal Cancer Liver Metastases

Schindl

Wigmore²,

Currie³

et al. 2005

Arch Surg

118

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“…An increased expression of liver ALP at the surface of hepatocyte plasma membranes, accompanied by the shedding of liver plasma membrane fragments is thought to be responsible for the presence of BALP in these patients (Van Hoof and De Broe 1994;Deng et al 1996). The clinical value of the BALP isoform in detecting liver metastasis has been evaluated by several investigators (Viot et al 1981;Viot et al 1983;Karmen et al 1984;Nishio et al 1986;Yeh et al 1989;Yorio et al 2000).…”

Section: Introductionmentioning

confidence: 99%

Clinical value of biliary alkaline phosphatase in non-jaundiced cholangiocarcinoma

Bhudhisawasdi

Muisuk

Areejitranusorn

et al. 2004

Journal of Cancer Research and Clinical Oncology

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Diagnostic value of high molecular weight alkaline phosphatase in detection of hepatic metastasis in patients with lung cancer

Nishio

Sakuma

Nakamura

et al. 1986

Cancer

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High molecular weight alkaline phosphatase (HMW-ALP) was measured in the sera of 126 patients with lung cancer to determine its diagnostic value in the detection of hepatic metastasis. This isoenzyme was found in 21 of 24 patients with hepatic metastasis and in 27 of 102 patients without hepatic metastasis. When 10 U/L was used as a cut-off value, the sensitivity, specificity, and accuracy of this test were 71%, 89%, and 86%, respectively. From the standpoint of histologic type, this test was most useful in patients with small cell carcinoma. HMW-ALP was not detected in the sera of 15 controls. It is concluded that HMW-ALP is a useful marker for hepatic metastasis in patients with lung cancer.

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α1 Isoenzyme of alkaline phosphatases clinical importance and value for the detection of liver metastases

Cited by 17 publications

References 12 publications

Prognostic Scoring in Colorectal Cancer Liver Metastases

Prognostic Scoring in Colorectal Cancer Liver Metastases

Clinical value of biliary alkaline phosphatase in non-jaundiced cholangiocarcinoma

Diagnostic value of high molecular weight alkaline phosphatase in detection of hepatic metastasis in patients with lung cancer

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