Clinical value of biliary alkaline phosphatase in non-jaundiced cholangiocarcinoma

Abstract

The demonstration of serum BALP, in particular in non-jaundiced patients with high serum ALP, may indicate the presence of tumor in the bile duct.

Ability of Biochemical Parameters to Distinguish between Bile Duct Cancer and Gall Bladder Stones - A Case Control Study in a Tertiary Care Hospital of Pokhara Valley

“…In both cancer and stone cases, mildly raised AST and ALT suggested the very less injury to hepatocytes. The serum alkaline phosphatase was markedly raised in cancer cases 251.5± 20.1IU/L (241.8, 261.1) when compared to stone cases 173.2±12.6IU/L (169.5, 176.9) and controls 84.5±13.5 IU/L (78.1, 90.1) due to more severe injury to bile duct epithelial cells in cancer cases (p: 0.0001*) (Bhudhisawasdi et al, 2004). Furthermore, it was more raised in females owing to increased bone turn over or simultaneous formation of osteoid.…”

Changes in serum, liver, and brain high and low molecular weight alkaline phosphatase following manganese toxicity in rats

“…Biliary ALP or high molecular weight ALP was found in the serum of patients with biliary obstruction and metastatic liver cancer (Bhudhisawasdi, Musik, and Areejitransuorn 2004). Previous studies from our lab showed that high molecular weight ALP might be considered as a tumor marker for liver cancer (Moshtaghie, Ani, and Soltani 1996).…”

“…The incidence of this form of ALP may be associated with hepatic malignancy (Bhudhisawasdi, Musik, and Areejitransuorn 2004), and thus may be considered as a biomarker in such patients. As a model for hepatic damage, the existence of this isoenzyme was investigated in sera of Mn-treated animals, which is the major aim of the current study.…”

Impact Factors for Microinvasion in Intrahepatic Cholangiocarcinoma: A Possible System for Defining Clinical Target Volume

“…The shedding of an overloaded membrane-bound liver ALP into the circulation has been shown to result from obstruction of the biliary tree. The presence of serum biliary ALP may indicate the presence of a tumor in the bile duct, particularly in nonjaundiced patients with high serum ALP levels (>147 U/L) (21).…”