Ability of Biochemical Parameters to Distinguish between Bile Duct Cancer and Gall Bladder Stones - A Case Control Study in a Tertiary Care Hospital of Pokhara Valley

Association of Cytochrome-17 (MspA1) Gene Polymorphism with Risk of Gall Bladder Stones and Cancer in North India

“…Similarly, the comparison between the all study group (cancer, stone and cancer+stone) and control group shows that the level of TC, TG, LDL, VLDL, estrogen was significantly higher and HDL was significantly lower among the all study groups. Thus, in our study the significant higher level of TC, TG, LDL, VLDL, estrogen and lower HDL level among the patients of gallbladder cancer and gallstone indicating a significant association of lipid as well as estrogen metabolism in the etiology of disease and the findings were in agreement with previous report (Mohr et al, 1991;Channa et al, 2010;Dwivedi et al, 2013Singh et al, 2013Yadav et al, 2013). In postmenopausal women, hormone replacement therapy was significantly associated with the gallbladder diseases (Gallus et al, 2002;Cirillo et al, 2005) and suggesting that a noteworthy role of sex hormones in the etiology of gallbladder cancer (Nakamura et al, 1989;Khan et al, 1999;Zhang et al, 2013).…”

“…These changes in bile composition are closely related to the disorders of lipid metabolism in liver (Small, 1967;Admirand et al, 1968). Several studies have reported that gallbladder cancer and gallstone patients had hyperlipidemia (Mohr et al, 1991;Channa et al, 2010;Yadav et al, 2013;Singh et al, 2013;Dwivedi et al, 2013). The findings of our study were agreement with these reports, as in our study the serum level of total cholesterol, triglyceride, low density lipoprotein and very low density lipoprotein was found significantly higher in all study group, and high density lipoprotein was significantly lower in study group compared with control subjects.…”