α-Tocopherol release from active polymer films loaded with functionalized SBA-15 mesoporous silica

Gargiulo, Nicola; Attianese, Ilaria; Buonocore, Giovanna G.; Caputo, Domenico; Lavorgna, Margherita; Mensitieri, Giuseppe; Lavorgna, Marino

doi:10.1016/j.micromeso.2012.07.037

Cited by 43 publications

(60 citation statements)

References 26 publications

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“…A more significant intensity decrease is observed for the functionalized and quercetin loaded mesoporous samples, which can be explained not only by the decreased amount of silica, but with some pore filling effect by quercetin (Supplementary data, S1), reducing the scattering contrast between the pores and the silica matrix [30].…”

Section: Materials Characterizationmentioning

confidence: 96%

Experimental and theoretical study of quercetin complexes formed on pure silica and Zn-modified mesoporous MCM-41 and SBA-16 materials

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Szegedi

et al. 2016

Microporous and Mesoporous Materials

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SBA-16 and MCM-41 silica materials were synthesized and modified by post-synthesis method with different amounts of Zn (2 and 4 wt.%). Quercetin, a flavonol compound, was loaded by incipient wetness impregnation method on the pure silica and Zn-modified mesoporous MCM-41 and SBA-16 supports. The parent and drug loaded formulations were characterized by powder XRD, N 2 physisorption, thermal analysis, TEM, UV Vis and FT-IR spectroscopies. The formation of Zn:quercetin complex was studied by FT-IR spectroscopy and quantum-chemical calculations. Loading of quercetin on mesoporous carriers made the sustained delivery of the bioactive compound possible in a buffer with pH = 5.5, typical of dermal formulations. The results from the release experiments are in good accordance with the inter-action energy between the bioactive molecule and non-modified and Zn-modified mesoporous materials, predicted by the quantum-chemical calculations. For the first time the formation of the most stable Zn quercetin complexes loaded on the mesoporous silica materials were determined. The obtained mesoporous delivery systems with Zn-quercetin complex are promising as dermal formulations.

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Section: Materials Characterizationmentioning

confidence: 96%

Experimental and theoretical study of quercetin complexes formed on pure silica and Zn-modified mesoporous MCM-41 and SBA-16 materials

Popova

Trendafilova

Szegedi

et al. 2016

Microporous and Mesoporous Materials

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“…Foods with high fat content are susceptible to lipid oxidation; this process involves different reactions resulting in the formation of undesirable odors that make the product unacceptable by the consumers (Granda-Restrepo et al 2009;Gargiulo et al 2013). In the food industry, direct addition of antioxidant agents into the products is a common practice aimed to prevent the quality deterioration caused by the oxidative rancidity.…”

Section: Introductionmentioning

confidence: 99%

“…In the food industry, direct addition of antioxidant agents into the products is a common practice aimed to prevent the quality deterioration caused by the oxidative rancidity. Nevertheless, this approach presents some drawbacks such as that large amounts of the antioxidants are needed, in some cases there are established maximum permitted levels by food legislation, and moreover at high concentrations they can act as pro-oxidants (Gargiulo et al 2013). In past years the antioxidant active packaging appeared as an innovative technology that may supply a sustained delivery of the active compound, maintaining an effective concentration over the time (Zhu et al 2012).…”

Section: Introductionmentioning

confidence: 99%

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Preparation of antioxidant active films based on chitosan: diffusivity study of α-tocopherol into food simulants

et al. 2016

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New active films based on chitosan and polycaprolactone blends and containing α-tocopherol were designed for food packaging applications. Mechanical properties, stability against temperature and swelling degree in 50 % ethanol (v/v) were evaluated. Migration kinetics of α-tocopherol from the developed films into butter and food simulants [50 % ethanol (v/v), 95 % ethanol (v/v), and isooctane] at different temperatures were studied. α-Tocopherol was quantified in the food simulants by means of high performance liquid chromatography with diode-array detection at 292 nm. The proposed method exhibited a good sensitivity with a limit of detection of 0.1 mg/L. The kinetics release of α-tocopherol was characterized by determining the partition and the diffusion coefficients by using a mathematical modeling based on Fick's Second Law. The diffusion coefficients obtained ranged between 1.03 × 10(-13) and 2.24 × 10(-12) cm(2)/s for 95 % ethanol (v/v) at 4 and 20 °C, respectively. Developed films maintained the antioxidant activity for more than 20 days.

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“…More recently, Gargiulo et al (2013) proposed the encapsulation of -tocopherol in SBA-15 and its use as an alternative antioxidant for polymer protection during processing and also as an additive for active packaging systems.…”

Section: -Tocopherolmentioning

confidence: 99%

Use of silica supports for enhancing the stability of folates and developing antimicrobial agents

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Acknowledgements AgradecimientosLlegados a este punto me gustaría dar las gracias a todas las personas que me han ayudado de una forma u otra a la realización de esta tesis.A Jose por ofrecerme la oportunidad de hacer la tesis en su grupo de investigación, su apoyo y su total confianza. A Loles por su apoyo durante estos años resolviendo dudas sobre materiales y química. A Édgar por guiarme desde el primer momento que empecé a trabajar en esta línea de investigación, su amistad y su fundamental ayuda para la realización de esta tesis.A Ramón y Félix por su ayuda siempre que la he necesitado. A Isa y Ana por su acogida en el laboratorio desde el primer día y por su apoyo y consejo en todo momento. A Ana Jiménez y Amparo Quiles por su colaboración y acogida en sus laboratorios.A mis compañeros, o mejor dicho amigos, con los que he compartido esta etapa del doctorado. Gracias por hacer el trabajo más fácil, por vuestra amistad, risas, cenas, viajes y mucho más.A mis amigos por su apoyo y consuelo siempre, a pesar del paso del tiempo y la distancia que nos separa.A mi familia por estar siempre a mi lado. A mi hermana por ser mi referente y a mis padres por su preocupación y apoyo incondicional. Resumen ResumenLa presente tesis doctoral, que lleva por título "Uso de soportes de sílice para la mejora de la estabilidad de los folatos y el desarrollo de agentes antimicrobianos", se centra en el desarrollo y evaluación de nuevos sistemas inteligentes basados en el uso de nano-y micropartículas de sílice como soporte inorgánico para la encapsulación o inmovilización de dos tipos de compuestos de interés para la industria alimentaria: vitaminas y antimicrobianos.El primer capítulo muestra el efecto de la encapsulación de ácido fólico y 5-formiltretahidrofolato en micropartículas mesoporosas de sílice funcionalizadas con poliaminas sobre la bioaccessibilidad y estabilidad de ambos vitámeros. Por una parte, el uso de este soporte híbrido orgánico-inorgánico permite modular la liberación de la vitamina en función del pH del medio (inhibición de la liberación a pH ácido -estómago-y liberación controlada a pH neutro -intestino-) en sistemas in vitro. Así mismo, el soporte mesoporoso es capaz de proteger a la vitamina frente a la degradación tras la exposición a diversos agentes externos, como el pH, la temperatura o la luz. Además, la incorporación de ácido fólico encapsulado a zumos de frutas (manzana y naranja) ha permitido estudiar la capacidad moduladora y protectora del sistema de liberación en una matriz alimentaria real.Este estudio ha demostrado que el soporte funcionalizado con poliaminas no sólo es capaz de mantener el ácido fólico en el interior de los poros tras la incorporación a los zumos y modular correctamente la liberación del mismo tras la simulación de una digestión in vitro, sino que también es capaz de proteger la vitamina tras la simulación del procesado y almacenamiento de los zumos. Por tanto, el sistema de liberación propuesto puede ser una excelente alternativa a la fortificación directa para mantener ...

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α-Tocopherol release from active polymer films loaded with functionalized SBA-15 mesoporous silica

Cited by 43 publications

References 26 publications

Experimental and theoretical study of quercetin complexes formed on pure silica and Zn-modified mesoporous MCM-41 and SBA-16 materials

Experimental and theoretical study of quercetin complexes formed on pure silica and Zn-modified mesoporous MCM-41 and SBA-16 materials

Preparation of antioxidant active films based on chitosan: diffusivity study of α-tocopherol into food simulants

Use of silica supports for enhancing the stability of folates and developing antimicrobial agents

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