α-Tocopherol encapsulation and in vitro release from wheat gliadin nanoparticles

Abstract

Alpha-tocopherol, or vitamin E (VE), is widely used as a strong antioxidant in many medical and cosmetic applications, but is rapidly degraded, because of its light, heat and oxygen sensitivity. Thus, all of its formulation has to avoid contact with light, heat or air. Drug loaded carriers are an attractive opportunity, especially if they are made for bioacceptable macromolecules such as vegetal proteins. For instance, gliadins, extracted from wheat gluten, generate nanoparticles by a desolvatation method and may interact with epidermal keratin for therapeutic or cosmetic formulations. Their lipophilic drug loading capacities have been investigated. The VE loaded gliadin nanoparticles have been characterized by their size, by their zeta potential, by their VE payload, and by their entrapment efficiency. When VE loaded, the gliadin particle size is approximately 900 nm and their charge is close to zero. They are suitable VE drug carriers with an optimum encapsulation rate approximately 100 VE microg/gliadin mg with an efficiency of more than 77%. The release behaviour of VE loaded nanoparticles may be interpreted as a 'burst effect', followed by a diffusion process through an homogeneous sphere.

Curcumin loaded self assembled lipid-biopolymer nanoparticles for functional food applications

“…This type of constant decrease in encapsulation efficiency of active ingredient was also observed in another independent study where hydrophobic nutraceutical ingredient (vitamin E) was encapsulated in wheat gliadin nanoparticles. It was found that 900.0 nm sized nanoencapsulated vitamin E particles were formed with encapsulation efficiency of 95-77 % in increasing order of vitamin E concentration relative to gliadin weight (Duclairoir et al 2002). The decrease in fraction of spontaneously forming cavities of nanoassemblies to the added curcumin amount could be the reason behind aggregation of the nanoparticles and precipitation of curcumin beyond this concentration.…”

Chitosan-coated nanoliposome as vitamin E carrier

“…The method to determine the loading efficiency of VE was referenced from 21 . About 1 mg of chitosan-coated liposomes was digested in 10 ml of the ethanol/water mixture at 25 C in the dark.…”

“…The phenolic hydroxyl group of vitamin E donates hydrogen atoms, acting as a membrane stabilizing agent and free radical scavenger which can prevent the peroxidation of the polyunsaturated fatty acyl chains of membrane lipids [20][21][22][23] .…”

α-Tocopherol loaded thermosensitive polymer nanoparticles: preparation, in vitro release and antioxidant properties

“…The use of nanoparticles besides improving solubility in water, also provides controlled releasing. Some materials such as gliadin nanoparticles [5] , self-assembled nanoparticles of tocopheryl monoesters modified-chitosan conjugates [6] , and chitosan nanoparticles coated with zein [7] have been reported.…”