α<sup>+</sup>‐Thalassemia Protects against Anemia Associated with Asymptomatic Malaria: Evidence from Community‐Based Surveys in Tanzania and Kenya

Veenemans, Jacobien; Andang’o, Pauline; Mbugi, Erasto V.; Kraaijenhagen, Rob J.; Mwaniki, Dennis; Mockenhaupt, Frank P.; Roewer, Susanne; Olomi, Raimos; Shao, John F.; Meer, J.W.M. van der; Savelkoul, H.F.J.; Verhoef, Hans

doi:10.1086/589884

Cited by 35 publications

(49 citation statements)

References 37 publications

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“…This compares to other works that have suggested that alpha+ thalassaemia might limit the decline in haemoglobin that is not only confined to severe malaria cases but even so the protective effect might be evident when the Plasmodium falciparum infection is accompanied by inflammation (Veenemans et al, 2008).…”

contrasting

confidence: 74%

“…Malaria generally causes haemolysis and therefore a reduction in the haemoglobin concentration. However, among alpha + -thalassaemic patients is a gradual decline in the haemoglobin concentration (Veenemans et al, 2008) thus conferring protection against SMA in children.…”

Section: Discussionmentioning

confidence: 99%

“…However, observations by Veenemans et al,(2008) showed that alpha+-thalassaemia actually limits the decline in haemoglobin concentration associated with afebrile Plasmodium falciparum infection. The effect of alpha + -thalassaemia on haemoglobin level was observed among Tanzanian children with uncomplicated malaria (Enevold et al, 2008) where alpha + -thalassaemias were found to be associated with reduced haemoglobin levels.…”

mentioning

confidence: 99%

“…The protection conferred by alpha+thalassaemia is however, observed to be limited to the severe manifestation of Plasmodium falciparum malaria (Veenemans et al, (2008).…”

mentioning

confidence: 99%

“…Alpha + -thalassaemia has been implicated to independently associate with reduced expression of red cell CR1 and thus reduce the ability of red cells to form rosettes, (Clark, et al, 2003, Williams, et al, 2005a leading to protection against malarial complications In the opinion of Veenemans et al, (2008) alpha + -thalassaemia confers protection against SMA in children by preventing a gradual decline in haemoglobin concentration during repeated or chronic infection.…”

mentioning

confidence: 99%

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An investigation of the protective effect of alpha+‐thalassaemia against severe Plasmodium falciparum amongst children in Kumasi, Ghana

Opoku-Okrah

Gordge

Nakua

et al. 2013

Int J Lab Hematology

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This is an electronic version of a PhD thesis awarded by the University of Westminster. © The Author, 2012. This is an exact reproduction of the paper copy held by the University of Westminster library.The WestminsterResearch online digital archive at the University of Westminster aims to make the research output of the University available to a wider audience. Copyright and Moral Rights remain with the authors and/or copyright owners. Users are permitted to download and/or print one copy for non-commercial private study or research. Further distribution and any use of material from within this archive for profit-making enterprises or for commercial gain is strictly forbidden.Whilst further distribution of specific materials from within this archive is forbidden, you may freely distribute the URL of WestminsterResearch: (http://westminsterresearch.wmin.ac.uk/).In case of abuse or copyright appearing without permission email repository@westminster.ac.uk

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contrasting

confidence: 74%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

“…The protection conferred by alpha+thalassaemia is however, observed to be limited to the severe manifestation of Plasmodium falciparum malaria (Veenemans et al, (2008).…”

mentioning

confidence: 99%

mentioning

confidence: 99%

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An investigation of the protective effect of alpha+‐thalassaemia against severe Plasmodium falciparum amongst children in Kumasi, Ghana

Opoku-Okrah

Gordge

Nakua

et al. 2013

Int J Lab Hematology

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Host genetics

Williams

2016

Advances in Malaria Research

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Association between sickle cell anemia and alpha thalassemia reveals a high prevalence of the α^3.7 triplication in congolese patients than in worldwide series

Mikobi

Lukusa

Aloni

et al. 2017

Clinical Laboratory Analysis

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Background Information about the association with alpha thalassemia in sickle cell patients is unknown in the Democratic Republic of Congo. There is very little data on the alpha thalassemia in patients suffering from sickle cell anemia in Central Africa, and their consequences on the clinical expression of the disease. Methods A cross‐sectional study was conducted in 106 sickle cell patients living in the country's capital Kinshasa. The diagnosis of sickle cell anemia was confirmed with a molecular test using PCR‐RFLP (restriction fragment length polymorphism) technique. The diagnosis of thalassemia was performed by the technique of multiplex ligation dependent probe amplification. Results The mean age of our patients was 22.4±13.6 years. The α3.7 heterozygous deletion, the α3.7 homozygous deletion and the α3.7 triplication were respectively encountered in 23.6%, 25.5% , and 11.3% of patients. Patients with normal αα/αα genotype represented 39.6% of the study population. The average of severe vaso‐occlusive crises, the rates of blood transfusions per year, the rate of osteonecrosis, cholelithiasis and leg ulcers were significantly lower in the group of patients with α3.7 homozygous deletion and α3.7 triplication. Conclusion The prevalence of α3.7 triplication was higher in sickle cell patients in the Democratic Republic of Congo than in worldwide series. The α3.7 triplication and α3.7 homozygous deletion were associated with less severe forms of the Sickle cell anemia in Congolese patients. These results showed the need to investigate systematically the alpha‐globin gene mutations in sickle cell population in Central Africa.

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α⁺‐Thalassemia Protects against Anemia Associated with Asymptomatic Malaria: Evidence from Community‐Based Surveys in Tanzania and Kenya

Abstract: alpha(+)-Thalassemia limits the decline in hemoglobin concentration that is associated with afebrile infections, particularly those that are accompanied by inflammation.

Cited by 35 publications

References 37 publications

An investigation of the protective effect of alpha+‐thalassaemia against severe Plasmodium falciparum amongst children in Kumasi, Ghana

An investigation of the protective effect of alpha+‐thalassaemia against severe Plasmodium falciparum amongst children in Kumasi, Ghana

Host genetics

Association between sickle cell anemia and alpha thalassemia reveals a high prevalence of the α^3.7 triplication in congolese patients than in worldwide series

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α+‐Thalassemia Protects against Anemia Associated with Asymptomatic Malaria: Evidence from Community‐Based Surveys in Tanzania and Kenya

Abstract: alpha(+)-Thalassemia limits the decline in hemoglobin concentration that is associated with afebrile infections, particularly those that are accompanied by inflammation.

Cited by 35 publications

References 37 publications

An investigation of the protective effect of alpha+‐thalassaemia against severe Plasmodium falciparum amongst children in Kumasi, Ghana

An investigation of the protective effect of alpha+‐thalassaemia against severe Plasmodium falciparum amongst children in Kumasi, Ghana

Host genetics

Association between sickle cell anemia and alpha thalassemia reveals a high prevalence of the α3.7 triplication in congolese patients than in worldwide series

Contact Info

Product

Resources

About

α⁺‐Thalassemia Protects against Anemia Associated with Asymptomatic Malaria: Evidence from Community‐Based Surveys in Tanzania and Kenya

Association between sickle cell anemia and alpha thalassemia reveals a high prevalence of the α^3.7 triplication in congolese patients than in worldwide series