α-Pyrone Polyketides from Streptomyces ambofaciens BI0048, an Endophytic Actinobacterial Strain Isolated from the Red Alga Laurencia glandulifera

Rab, Eniko; Kekos, Dimitris; Roussis, Vassilios; Iοannou, Efstathia

doi:10.3390/md15120389

Cited by 14 publications

(10 citation statements)

References 19 publications

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“…5-Deoxy-enterocin was reported to be active against S. lutea, S. aureus, Klebsiella pneumoniae, and Vibrio percolans. Germicidin A displayed weak activity against Streptomyces viridochromogenes and Streptomyces griseus [177].…”

Section: Polyketides Polyketides Derived From the Brown Algae Associated Actinomycetesmentioning

confidence: 99%

“…Mar. Drugs 2021, 19, x FOR PEER REVIEW 45 of 58 separated from Streptomyces ambofaciens BI0048 associated with red alga Laurencia glandulifera [177]. Geosmin (S195), the compound responsible for the "earth smell" and betapatchoulene (S196) used as a fragrance agent in the perfume industry, were two major metabolites of Streptomyces carnosus M-40 [168].…”

Section: Other Structure Classesmentioning

confidence: 99%

“…And a novel bioactive antimicrobial kocumarin (338) (Figure 20) was produced by Kocuria marina CMG S 2 associated with brown macroalga Pelvetia canaliculata attached to the rocks of Sonmiani Beach and demonstrated prominent and rapid growth inhibition against all tested fungi and pathogenic bacteria [182]. Three known compounds benzoic acid (S158), hydrocinnamic acid (S193), and (E)-cinnamic acid(S194) were separated from Streptomyces ambofaciens BI0048 associated with red alga Laurencia glandulifera [177].…”

Section: Data Analysis Of the Secondary Metabolites From Actinomycetes Associated To Various Hostsmentioning

confidence: 99%

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Natural Products from Actinomycetes Associated with Marine Organisms

Chen

Zhou

et al. 2021

Marine Drugs

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The actinomycetes have proven to be a rich source of bioactive secondary metabolites and play a critical role in the development of pharmaceutical researches. With interactions of host organisms and having special ecological status, the actinomycetes associated with marine animals, marine plants, macroalgae, cyanobacteria, and lichens have more potential to produce active metabolites acting as chemical defenses to protect the host from predators as well as microbial infection. This review focuses on 536 secondary metabolites (SMs) from actinomycetes associated with these marine organisms covering the literature to mid-2021, which will highlight the taxonomic diversity of actinomycetes and the structural classes, biological activities of SMs. Among all the actinomycetes listed, members of Streptomyces (68%), Micromonospora (6%), and Nocardiopsis (3%) are dominant producers of secondary metabolites. Additionally, alkaloids (37%), polyketides (33%), and peptides (15%) comprise the largest proportion of natural products with mostly antimicrobial activity and cytotoxicity. Furthermore, the data analysis and clinical information of SMs have been summarized in this article, suggesting that some of these actinomycetes with multiple host organisms deserve more attention to their special ecological status and genetic factors.

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Section: Polyketides Polyketides Derived From the Brown Algae Associated Actinomycetesmentioning

confidence: 99%

Section: Other Structure Classesmentioning

confidence: 99%

Section: Data Analysis Of the Secondary Metabolites From Actinomycetes Associated To Various Hostsmentioning

confidence: 99%

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Natural Products from Actinomycetes Associated with Marine Organisms

Chen

Zhou

et al. 2021

Marine Drugs

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“…In addition to medicine, Greek strains have potential applications in the field of agriculture as biocontrol agents and growth promoters [9][10][11]. Each of these streptomycetes produces multiple secondary metabolites; for example, Streptomyces ambofaciens BI0048, an endophyte isolated from the red alga Laurencia glandulifera from Attiki, produced 10 different α-pyrone polyketides as well as benzoic acid, hydrocinnamic acid and (E)-cinnamic acid [12]. Other examples include Streptomyces sp.…”

Section: Introductionmentioning

confidence: 99%

Streptomyces, Greek Habitats and Novel Pharmaceuticals: A Promising Challenge

Laskaris

Karagouni

2021

Microbiology Research

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Bacteria of the genus Streptomyces produce a very large number of secondary metabolites, many of which are of vital importance to modern medicine. There is great interest in the discovery of novel pharmaceutical compounds derived from strepomycetes, since novel antibiotics, anticancer and compounds for treating other conditions are urgently needed. Greece, as proven by recent research, possesses microbial reservoirs with a high diversity of Streptomyces populations, which provide a rich pool of strains with potential pharmaceutical value. This review examines the compounds of pharmaceutical interest that have been derived from Greek Streptomyces isolates. The compounds reported in the literature include antibiotics, antitumor compounds, biofilm inhibitors, antiparasitics, bacterial toxin production inhibitors and antioxidants. The streptomycete biodiversity of Greek environments remains relatively unexamined and is therefore a very promising resource for potential novel pharmaceuticals.

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“…α-Pyrones are one of polyketide-biosynthetic skeletons, characterized by six-membered unsaturated cyclic scaffold containing a lactone [7]. α-Pyrones can be widely found in the fungi and actinomycetes [8,9,10], and these molecules demonstrated a wide range of extraordinary biological activities, such as antimicrobial [11], anti-inflammatory [12], cytotoxic [13], and quorum sensing signaling molecules [14,15].…”

Section: Introductionmentioning

confidence: 99%

Production of New Antibacterial 4-Hydroxy-α-Pyrones by a Marine Fungus Aspergillus niger Cultivated in Solid Medium

Ding

Ren

et al. 2019

Marine Drugs

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Four 4-hydroxy-α-pyrones including three new ones named nipyrones A–C (1–3) together with one known analogue germicidin C (4) were discovered from a marine sponge-derived fungus Aspergillus niger cultivated in a solid rice culture. Their structures and absolute configurations were elucidated through a combination of spectroscopic data and electronic circular dichroism (ECD) calculations as well as comparison with literature data. Compounds 1–4 were evaluated for their antibacterial activities against five pathogenic bacteria (Staphylococcus aureus, Escherichia coli, Bacillus subtilis, methicillin-resistant Staphylococcus aureus, and Mycobacterium tuberculosis). Compound 3 showed promising activity against S. aureus and B. subtilis, with minimum inhibitory concentration (MIC) values of 8 μg/mL and 16 μg/mL, respectively, and displayed weak antitubercular activities against M. tuberculosis, with MIC value of 64 μg/mL, while compounds 1 and 2 exhibited moderate antibacterial efficacy against four pathogenic bacteria with MIC values of 32–64 μg/mL.

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α-Pyrone Polyketides from Streptomyces ambofaciens BI0048, an Endophytic Actinobacterial Strain Isolated from the Red Alga Laurencia glandulifera

Cited by 14 publications

References 19 publications

Natural Products from Actinomycetes Associated with Marine Organisms

Natural Products from Actinomycetes Associated with Marine Organisms

Streptomyces, Greek Habitats and Novel Pharmaceuticals: A Promising Challenge

Production of New Antibacterial 4-Hydroxy-α-Pyrones by a Marine Fungus Aspergillus niger Cultivated in Solid Medium

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