α-Lipoic acid induces Endoplasmic Reticulum stress-mediated apoptosis in hepatoma cells

Pibiri, Monica; Sulas, Pia; Camboni, Tania; Leoni, Vera P.; Simbula, Gabriella

doi:10.1038/s41598-020-64004-5

Cited by 19 publications

(9 citation statements)

References 57 publications

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“…This evidence supports our findings between the two cell models. Other antioxidants such as luteolin [ 35 ] and α-lipoic acid [ 37 ] have also been related to ROS-induced cell death in cancer cells.…”

Section: Discussionmentioning

confidence: 99%

Low Doses of Resveratrol Protect Human Granulosa Cells from Induced-Oxidative Stress

et al. 2021

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Resveratrol is a phytoalexin present in plant-derived foods, including grape’s skin, cocoa, and peanuts. Evidence suggests that it has beneficial effects on human health because of its antioxidant properties. However, there is limited knowledge about the part played by resveratrol in ovarian function. In this paper, the influence of resveratrol on granulosa cells (GC) was evaluated. In addition to being the main estradiol producers, GC are in direct contact with the oocyte, playing a fundamental role in its growth and development. The cell line COV434 and human granulosa cells (hGC), obtained from women undergoing assisted reproductive technology (ART), were used. GC were treated with resveratrol (0.001–20 μM) at different times (24–72 h). Low concentrations of this compound suggest a protective role, as they tend to reduce ROS/RNS formation after inducement of stress. On the contrary, high concentrations of resveratrol affect GC viability and steroidogenic function. As it may act as a direct modulator of GC oxidative balance, this work may help to clarify the impact of resveratrol on GC and the usefulness of this antioxidant as adjunct to infertility treatments.

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Section: Discussionmentioning

confidence: 99%

Low Doses of Resveratrol Protect Human Granulosa Cells from Induced-Oxidative Stress

et al. 2021

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“…ER stress led to activation of PERK (phospho- extracellular signal-related kinase) pathway and IRE1 (inositol-requiring enzyme 1) pathway leading to apoptosis. α-lipoic acid also inhibited ATF6 (activating transcription factor 6)-mediated pro-survival pathway [ 72 ].…”

Section: Phytochemicals: a Promising Role In Ros Mediated Cancer Cmentioning

confidence: 99%

Role of Phytochemicals in Perturbation of Redox Homeostasis in Cancer

Srivastava

2021

Antioxidants

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Over the past few decades, research on reactive oxygen species (ROS) has revealed their critical role in the initiation and progression of cancer by virtue of various transcription factors. At certain threshold values, ROS act as signaling molecules leading to activation of oncogenic pathways. However, if perturbated beyond the threshold values, ROS act in an anti-tumor manner leading to cellular death. ROS mediate cellular death through various programmed cell death (PCD) approaches such as apoptosis, autophagy, ferroptosis, etc. Thus, external stimulation of ROS beyond a threshold is considered a promising therapeutic strategy. Phytochemicals have been widely regarded as favorable therapeutic options in many diseased conditions. Over the past few decades, mechanistic studies on phytochemicals have revealed their effect on ROS homeostasis in cancer. Considering their favorable side effect profile, phytochemicals remain attractive treatment options in cancer. Herein, we review some of the most recent studies performed using phytochemicals and, we further delve into the mechanism of action enacted by individual phytochemicals for PCD in cancer.

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“…48 Hence, interfering with or reversing of hypoxia and its effects or identifying a suitable way to increase ROS level in tumor cells can reduce the drug resistance of tumors and improve the therapeutic effect. 32,49,50 In turn, tumor cell aerobic glycolysis can influence HIF-1α by upregulating glutamine. The TCA cycle is the hinge of metabolism of glucose, fat and amino acid.…”

Section: Hypoxic Microenvironmentmentioning

confidence: 99%

<p>Glucometabolic Reprogramming in the Hepatocellular Carcinoma Microenvironment: Cause and Effect</p>

Tian

Zhu

et al. 2020

CMAR

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Hepatocellular carcinoma (HCC) is a tumor that exhibits glucometabolic reprogramming, with a high incidence and poor prognosis. Usually, HCC is not discovered until an advanced stage. Sorafenib is almost the only drug that is effective at treating advanced HCC, and promising metabolism-related therapeutic targets of HCC are urgently needed. The "Warburg effect" illustrates that tumor cells tend to choose aerobic glycolysis over oxidative phosphorylation (OXPHOS), which is closely related to the features of the tumor microenvironment (TME). The HCC microenvironment consists of hypoxia, acidosis and immune suppression, and contributes to tumor glycolysis. In turn, the glycolysis of the tumor aggravates hypoxia, acidosis and immune suppression, and leads to tumor proliferation, angiogenesis, epithelial-mesenchymal transition (EMT), invasion and metastasis. In 2017, a mechanism underlying the effects of gluconeogenesis on inhibiting glycolysis and blockading HCC progression was proposed. Treating HCC by increasing gluconeogenesis has attracted increasing attention from scientists, but few articles have summarized it. In this review, we discuss the mechanisms associated with the TME, glycolysis and gluconeogenesis and the current treatments for HCC. We believe that a treatment combination of sorafenib with TME improvement and/or anti-Warburg therapies will set the trend of advanced HCC therapy in the future.

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α-Lipoic acid induces Endoplasmic Reticulum stress-mediated apoptosis in hepatoma cells

Cited by 19 publications

References 57 publications

Low Doses of Resveratrol Protect Human Granulosa Cells from Induced-Oxidative Stress

Low Doses of Resveratrol Protect Human Granulosa Cells from Induced-Oxidative Stress

Role of Phytochemicals in Perturbation of Redox Homeostasis in Cancer

<p>Glucometabolic Reprogramming in the Hepatocellular Carcinoma Microenvironment: Cause and Effect</p>

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