Role of Phytochemicals in Perturbation of Redox Homeostasis in Cancer

Srivastava, Sanjay

doi:10.3390/antiox10010083

Cited by 33 publications

(19 citation statements)

References 149 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Medicinal plants have made a significant contribution to the rapidly expanding discipline of natural product chemistry. Natural products have also been accepted as a significant source in satisfying the healthcare demands of many societies, as a result of several discoveries [9]. Hence, natural products are part of current and effective tools for developing novel pharmaceuticals, as well as a bank of pharmacological templates [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Thonningia sanguinea Extract: Antioxidant and Cytotoxic Activities Supported by Chemical Composition and Molecular Docking Simulations

Abdelhameed

Elhady

Sirwi

et al. 2021

Plants

View full text Add to dashboard Cite

The current study was designed to investigate the antioxidant and cytotoxic activities of Thonningia sanguinea whole-plant extract. The total phenolic content was determined using Folin–Ciocalteu reagent and found to be 980.1 mg/g, calculated as gallic acid equivalents. The antioxidant capacity was estimated for the crude extract and the phenolic portion of T. sanguinea, whereupon both revealed a dose-dependent scavenging rate of DPPH• with EC50 values of 36.33 and 11.14 µg/mL, respectively. Chemical profiling of the plant extract was achieved by LC-ESI-TOF-MS/MS analysis, where 17 compounds were assigned, including ten compounds detected in the negative mode and seven detected in the positive mode. The phenolic portion exhibited promising cytotoxic activity against MCF-7 and HepG2 cells, with IC50 values of 16.67 and 13.51 μg/mL, respectively. Phenolic extract treatment caused apoptosis in MCF-7 cells, with total apoptotic cell death 18.45-fold higher compared to untreated controls, arresting the cell cycle at G2/M by increasing the G2 population by 39.7%, compared to 19.35% for the control. The apoptotic investigation was further validated by the upregulation of proapoptotic genes of P53, Bax, and caspases-3,8 9, and the downregulation of Bcl-2 as the anti-apoptotic gene. Bcl-2 inhibition was also virtualized by good binding interactions through a molecular docking study. Taken together, phenolic extract exhibited promising cytotoxic activity in MCF-7 cells through apoptosis induction and antioxidant activation, so further fractionation studies are recommended for the phenolic extract for specifying the most active compound to be developed as a novel anti-cancer agent.

show abstract

Section: Introductionmentioning

confidence: 99%

Thonningia sanguinea Extract: Antioxidant and Cytotoxic Activities Supported by Chemical Composition and Molecular Docking Simulations

Abdelhameed

Elhady

Sirwi

et al. 2021

Plants

View full text Add to dashboard Cite

show abstract

“…Several studies have reported that there are higher levels of oxidative stress in cancer cells compared to normal cells due to their hypermetabolic state, which also disrupts cell death signaling, and causes drug resistance. Higher levels of oxidative stress enhance cancer cell survival, proliferation, angiogenesis, and metastasis [ 78 , 79 ]. Despite its tumorigenesis effect, this altered biochemical behavior of cancer cells can be exploited to yield therapeutic benefits.…”

Section: Effect Of Det and Idet On Apoptosis Pathwaysmentioning

confidence: 99%

“…Cellular organelles and macromolecules, such as DNA, lipids, and proteins, under excessive oxidative stress experience oxidative damage, leading to cell death. Several in vitro and in vivo studies have shown that ROS-generating phytochemicals could pose oxidative damage, therefore selectively cause apoptosis of cancer cells by ROS-mediated mechanisms [ 78 , 79 , 80 ].…”

Section: Effect Of Det and Idet On Apoptosis Pathwaysmentioning

confidence: 99%

Deoxyelephantopin and Its Isomer Isodeoxyelephantopin: Anti-Cancer Natural Products with Multiple Modes of Action

Mehmood

Muanprasat

2022

Molecules

View full text Add to dashboard Cite

Cancer is a leading cause of morbidity and mortality worldwide. The development of cancer involves aberrations in multiple pathways, representing promising targets for anti-cancer drug discovery. Natural products are regarded as a rich source for developing anti-cancer therapies due to their unique structures and favorable pharmacology and toxicology profiles. Deoxyelephantopin and isodeoxyelephantopin, sesquiterpene lactone compounds, are major components of Elephantopus scaber and Elephantopus carolinianus, which have long been used as traditional medicines to treat multiple ailments, including liver diseases, diabetes, bronchitis, fever, diarrhea, dysentery, cancer, renal disorders, and inflammation-associated diseases. Recently, deoxyelephantopin and isodeoxyelephantopin have been extensively explored for their anti-cancer activities. This review summarizes and discusses the anti-cancer activities of deoxyelephantopin and isodeoxyelephantopin, with an emphasis on their modes of action and molecular targets. Both compounds disrupt several processes involved in cancer progression by targeting multiple signaling pathways deregulated in cancers, including cell cycle and proliferation, cell survival, autophagy, and invasion pathways. Future directions of research on these two compounds towards anti-cancer drug development are discussed.

show abstract

“…Natural phytochemicals have been applied to the therapy of various diseases, including tumors (8). These phytochemicals can effectively inhibit the initiation, development and progression of neoplasm by regulating cellular proliferation, apoptosis and metastasis (9). Recent studies have indicated the important roles of natural compounds in modulating tumor angiogenesis by promoting the apoptosis of endothelial cell and inhibiting the angiogenesis-associated cytokines (10).…”

Section: Introductionmentioning

confidence: 99%

Natural Products: A Promising Therapeutics for Targeting Tumor Angiogenesis

Song

Guo

et al. 2021

Front. Oncol.

View full text Add to dashboard Cite

Tumor-associated angiogenesis is a key target for anti-cancer therapy. The imbalance between pro-angiogenic and anti-angiogenic signals elicited by tumor cells or tumor microenvironment always results in activating “angiogenic switch”. Tumor angiogenesis functions in multi-aspects of tumor biology, including endothelial cell apoptosis, tumor metastasis, and cancer stem cell proliferation. Numerous studies have indicated the important roles of inexpensive and less toxic natural products in targeting tumor angiogenesis-associated cytokines and apoptotic signaling pathways. Our current knowledge of tumor angiogenesis is based mainly on experiments performed on cells and animals, so we summarized the well-established models for angiogenesis both in vitro and in vivo. In this review, we classified and summarized the anti-angiogenic natural agents (Polyphenols, Polysaccharides, Alkaloids, Terpenoids, Saponins) in targeting various tumor types according to their chemical structures at present, and discussed the mechanistic principles of these natural products on regulating angiogenesis-associated cytokines and apoptotic signaling pathways. This review is to help understanding the recent progress of natural product research for drug development on anti-tumor angiogenesis.

show abstract

Role of Phytochemicals in Perturbation of Redox Homeostasis in Cancer

Cited by 33 publications

References 149 publications

Thonningia sanguinea Extract: Antioxidant and Cytotoxic Activities Supported by Chemical Composition and Molecular Docking Simulations

Thonningia sanguinea Extract: Antioxidant and Cytotoxic Activities Supported by Chemical Composition and Molecular Docking Simulations

Deoxyelephantopin and Its Isomer Isodeoxyelephantopin: Anti-Cancer Natural Products with Multiple Modes of Action

Natural Products: A Promising Therapeutics for Targeting Tumor Angiogenesis

Contact Info

Product

Resources

About