α-Lipoic acid attenuates coxsackievirus B3-induced ectopic calcification in heart, pancreas, and lung

Kim, Hyo Shin; Shin, Hong‐In; Lim, Hyun-Sook; Lee, Tae Yoon; Lee, Kyung‐Hee; Jeong, Daewon

doi:10.1016/j.bbrc.2013.01.061

Cited by 6 publications

(4 citation statements)

References 28 publications

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“…α-Lipoic acid (ALA) is made in the human body and is essential for aerobic metabolism and as a cofactor in several enzymatic reactions. There are no human studies of the effect of ALA on CV calcification but in mice with calcification from heart tissue injury, ALA lowered tissue damage and reduced calcification [ 146 ], while in rabbits it reduced aortic valve and medial calcification [ 121 , 147 ]. N -acetylcysteine (NAC) functions principally as a mucolytic agent and helps to increase endogenous glutathione levels.…”

Section: Antioxidantsmentioning

confidence: 99%

A Review of the Effect of Diet on Cardiovascular Calcification

Nicoll

Howard²,

Henein

2015

IJMS

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Cardiovascular (CV) calcification is known as sub-clinical atherosclerosis and is recognised as a predictor of CV events and mortality. As yet there is no treatment for CV calcification and conventional CV risk factors are not consistently correlated, leaving clinicians uncertain as to optimum management for these patients. For this reason, a review of studies investigating diet and serum levels of macro- and micronutrients was carried out. Although there were few human studies of macronutrients, nevertheless transfats and simple sugars should be avoided, while long chain ω-3 fats from oily fish may be protective. Among the micronutrients, an intake of 800 μg/day calcium was beneficial in those without renal disease or hyperparathyroidism, while inorganic phosphorus from food preservatives and colas may induce calcification. A high intake of magnesium (≥380 mg/day) and phylloquinone (500 μg/day) proved protective, as did a serum 25(OH)D concentration of ≥75 nmol/L. Although oxidative damage appears to be a cause of CV calcification, the antioxidant vitamins proved to be largely ineffective, while supplementation of α-tocopherol may induce calcification. Nevertheless other antioxidant compounds (epigallocatechin gallate from green tea and resveratrol from red wine) were protective. Finally, a homocysteine concentration >12 µmol/L was predictive of CV calcification, although a plasma folate concentration of >39.4 nmol/L could both lower homocysteine and protect against calcification. In terms of a dietary programme, these recommendations indicate avoiding sugar and the transfats and preservatives found in processed foods and drinks and adopting a diet high in oily fish and vegetables. The micronutrients magnesium and vitamin K may be worthy of further investigation as a treatment option for CV calcification.

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Section: Antioxidantsmentioning

confidence: 99%

A Review of the Effect of Diet on Cardiovascular Calcification

Nicoll

Howard²,

Henein

2015

IJMS

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“…4 a–d). Tissue staining for calcium was performed by Von Kossa, which stains calcium brownish to black [5] ( Fig. 4 e–h).…”

Section: Experimental Design Materials and Methodsmentioning

confidence: 99%

Histopathological data of iron and calcium in the mouse lung after asbestos exposure

et al. 2016

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This data article contains data related to the research article entitled, “Synchrotron X-ray microscopy reveals early calcium and iron interaction with crocidolite fibers in the lung of exposed mice” [1]. Asbestos fibers disrupt iron homeostasis in the human and mouse lung, leading to the deposition of iron (Fe) onto longer asbestos fibers which forms asbestos bodies (AB) [2]. Similar to Fe, calcium (Ca) is also deposited in the coats of the AB. This article presents data on iron and calcium in the mouse lung after asbestos exposure detected by histochemical evaluation.

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“…Ectopic calcification is the pathologic deposition of calcium salts in soft tissues (e.g., lungs, heart, kidney and blood vessels) caused by a viral infection, inflammation, and oxidant insults [223] , [224] , [225] . LA (10 mg/kg BW for 14 days) could decrease ectopic calcification in mouse lungs exposed to coxsackievirus B3 by reducing inflammatory damage and downregulating osteogenic gene expression [226] . This finding suggests that LA may be used to repair lung damage induced by common causes.…”

Section: Lipoic Acid and Respiratory Diseasesmentioning

confidence: 98%