The effects of lipoic acid on respiratory diseases

Guo, Xiang; Wu, Sijia; Shang, Jia; Dong, Wanglin; Li, Yuanyuan; Peng, Qianwen; Xie, Zhengjun; Chen, Chaoran

doi:10.1016/j.intimp.2023.109713

Cited by 4 publications

(1 citation statement)

References 234 publications

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“…Animal models have reported that ML-7, a potent myosin light-chain kinase (MLCK) inhibitor, impedes neutrophilic inflammation caused by LPS in various respiratory diseases [63]. Interestingly, RCC patients exhibited a high metabolism of lipoic acid but its beneficial role in ameliorating many respiratory diseases (e.g., lung cancer, fibrosis, asthma, and acute lung injury) has been suggested because it shows anti-oxidative and anti-inflammatory properties [64].…”

Section: Discussionmentioning

confidence: 99%

First Exploration of the Altered Microbial Gut–Lung Axis in the Pathogenesis of Human Refractory Chronic Cough

Baldi,

Fabbrizzi,

Di Gloria

et al. 2024

Lung

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Purpose Cough represents a natural mechanism that plays an important defensive role in the respiratory tract, but in some conditions, it may become persistent, nonproductive, and harmful. In general, refractory chronic cough (RCC) occurs in about 20% of individuals; hence, we aimed to assess the presence of altered gut–lung communication in RCC patients through a compositional and functional characterization of both gut (GM) and oral microbiota (OM). Methods 16S rRNA sequencing was used to characterize both GM and OM composition of RCC patients and healthy controls (HC). PICRUST2 assessed functional changes in microbial communities while gas chromatography was used to evaluate fecal short-chain fatty acid levels and serum-free fatty acid (FFA) abundances. Results In comparison with HC, RCC patients reported increased saliva alpha-diversity and statistically significant beta-diversity in both GM and OM. Also, a, respectively, significant increased or reduced Firmicutes/Bacteroidota ratio in stool and saliva samples of RCC patients has been shown, in addition to a modification of the abundances of several taxa in both GM and OM. Moreover, a potential fecal over-expression of lipopolysaccharide biosynthesis and lipoic acid metabolism pathways and several differences in serum FFA levels have been reported in RCC patients than in HC. Conclusion Since differences in both GM and OM of RCC patients have been documented, these findings could provide new information about RCC pathogenesis and also pave the way for the development of novel nutritional or pharmacological interventions for the management of RCC through the restoration of eubiotic gut–lung communication.

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Section: Discussionmentioning

confidence: 99%