α-Lipoic acid and ebselen prevent ischemia/reperfusion injury in the rat intestine

Abstract

alpha-Lipoic acid and ebselen played an important role in attenuating I/R injury of the intestine by scavenging ROS and RNS.

Pterostilbene prevents intestinal ischemia reperfusion injury in wistar rats via modulation of antioxidant defense and inflammation

“…However, treatment with pterostilbene offered protection against intestinal I/R injuryinduced oxidative stress. The present study results are in line with Guven et al [22], clearly showing the imbalance in redox homeostasis in IIR injury. The antioxidant effects of pterostilbene have been largely studied which is in line with the present research findings.…”

Beneficial Effects ofN-Acetylcysteine and Ebselen on Renal Ischemia/Reperfusion Injury

“…It has been shown that E could protect organs such as intestine, neurons, lungs, and myocardium against IRI. 6,[30][31][32] Taken together, E plays an important role in protection of kidneys against IRI experimentally. It may be a good candidate to prevent IRI in kidney transplantations but further studies should be conducted to evaluate its safety and efficacy in humans.…”

“…1,4,[6][7][8] The consequences of oxidative and nitrosative stresses are various and include lipid peroxidation, resulting in destruction of membrane lipids, and oxidative DNA damage, collectively leading to the loss of cell viability, either via necrotic or apoptotic pathways. 2 Some in vivo and in vitro investigations have also demonstrated that decrease in production or scavenging of ROS and RNS reduces the renal IRI.…”

Comparison of the Efficacy of Melatonin and 1400W on Renal Ischemia/Reperfusion Injury: A Role for Inhibiting iNOS

“…[1,[4][5][6][7][8] It is presumed that ROS production reduces the transcription of endothelial nitric oxide synthase (eNOS), which provides nitric oxide (NO) under physiologic circumstances. On the other hand, ROS/RNS activates inducible nitric oxide synthase (iNOS), which causes an almost 1,000-fold higher NO production than eNOS.…”

“…Once iNOS is activated, because of NO's affinity for O ; as a result, high peroxynitrite (ONOO − ) levels are elevated. [5,13,14] Because NO derived from iNOS also has an important role in I/R process, it is crucial to determine whether NO or ONOO − exerted these effects. [7,15] Various in vivo studies have shown that NO biosynthesis and its action are closely related to the pathogenesis of renal I/R injury.…”