α-(Imino)pyridyldifluoroethyl Phosphonates: Novel Promising Building Blocks in Synthesis of Biorelevant Aminophosphonic Acids Derivatives

Abstract

A convenient synthetic approach to previously unknown NH-iminophosphonates bearing 2-, 3-, and 4-pyridyldifluoromethyl groups at the imine carbon atom was developed. The synthetic potential of these novel building blocks was demonstrated by their conversion into highly functionalized acyclic and heterocyclic aminophosphonates and phosphonic acids combining in their structure biorelevant aminophosphonic fragment, difluoromethyl group, and pyridyl, piperidyl, thiazolidin-4-one, or thiazidinan-4-one heterocyclic moieties in a single molecular platform.

Special Issue “Progress in Synthesis and Applications of Phosphorus-Containing Compounds”

“…I wish to thank the Editorial Office and especially Ms. Stella Mao and Mr. Stephen Wang for their professional support and patience. It was a pleasure to serve as Guest Editor of this of Special Issue of Organics entitled "Progress in Synthesis and Applications of Phosphorus-Containing Compounds" [1] and I extend my gratitude to all the authors for their excellent contributions. Enjoy reading them!…”