Abstract::
The review highlights recent advancements in the synthesis of α-fluoro and α,α-
difluoroalkylated azines, focusing on two main approaches. The first approach involves nucleophilic
deoxofluorination, wherein α-hydroxy- or α-oxoalkylated azines are treated with diethylaminosulfur
trifluoride or other S-F reagents to introduce fluorine atoms. The second approach
employs direct electrophilic benzylic fluorination, whereby alkylazines undergo fluorination
using N-F reagents. Both methods provide flexibility in designing and synthesizing
fluoroalkylated heterocycles.