α-Glucosidase inhibitory effect of mulberry (Morus alba) leaves on Caco-2

Hansawasdi, Chanida; Kawabata, Jun

doi:10.1016/j.fitote.2006.09.003

Cited by 108 publications

(58 citation statements)

References 13 publications

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“…The α-glucosidase inhibitory effect of Morus alba was also observed in studies on Caco-2 cell cultures (Hansawasdi and Kawabata, 2006). Yang et al (2012) found 15 bioactive molecules (Tab.…”

Section: A Plant Extracts With Antidiabetic Actionmentioning

confidence: 60%

Plants and Natural Compounds with Antidiabetic Action

Coman

Rugină

Socaciu

2012

Not Bot Hort Agrobot Cluj

123

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Diabetes has become the most common metabolic disease worldwide. In particular, type 2 diabetes is the most commonly encountered type of diabetes, which is characterised by the inability of the organism to respond to normal levels of circulating insulin, also called insulin resistance. Current antidiabetic therapy is based on synthetic drugs that very often have side effects. For this reason, there is a continuous need to develop new and better pharmaceuticals as alternatives for the management and treatment of the disease. Natural hypoglycaemic compounds may be attractive alternatives to synthetic drugs or reinforcements to currently used treatments. Their huge advantage is that they can be ingested in everyday diet. Recently, more attention is being paid to the study of natural products as potential antidiabetics. This mini review of the current literature is structured into three main sections focused on: (a) plant extracts, (b) plant biomolecules, and (c) other natural molecules that have been used for their antidiabetic effects. Potential molecular mechanisms of action are also discussed.

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Section: A Plant Extracts With Antidiabetic Actionmentioning

confidence: 60%

Plants and Natural Compounds with Antidiabetic Action

Coman

Rugină

Socaciu

2012

Not Bot Hort Agrobot Cluj

123

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“…The glycemic reduction activity of 1 g/kg MA in diabetic rats was comparable with the activity of 4 U/kg/d insulin (−22%, Table 1). The ability of MA to lower fasting blood glucose levels in STZ-induced diabetic rats is probably mediated both by the stimulation of insulin release [7] and by the intestinal glucosidase inhibitory activity of the known mulberry-leaf component 1-deoxynojirimycin (DNJ) [14]. Singab et al [7] demonstrated that an oral administration of Egyptian Morus alba root bark extract for 3-10 days increased serum insulin levels in STZ-induced diabetic rat.…”

Section: Discussionmentioning

confidence: 99%

Antihyperglycemic, Antioxidant and Antiglycation Activities of Mulberry Leaf Extract in Streptozotocin-Induced Chronic Diabetic Rats

Naowaboot

Pannangpetch

Kukongviriyapan

et al. 2009

Plant Foods Hum Nutr

118

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In Thailand, beverages containing mulberry leaf (Morus alba L.) are believed to promote good health, especially in people with diabetes. We examined the effects of long-term administration of an ethanolic extract of mulberry leaf (MA) on blood glucose, oxidative damage, and glycation in streptozotocin-induced diabetic rats. Daily administration of 1 g/kg MA for six weeks decreased blood glucose by 22%, which was comparable to the effect of 4 U/kg insulin. Lipid peroxidation, measured as malondialdehyde and lipid hydroperoxide concentrations (3.50 +/- 0.33 and 3.76 +/- 0.18 muM, respectively) decreased significantly (P < 0.05) compared to nontreated control diabetic rats (8.19 +/- 0.45 and 7.50 +/- 0.46 muM, respectively). Hemoglobin A(1C), a biomarker for chronic exposure to high concentration of glucose, was also significantly decreased in the MA-treated group (6.78 +/- 0.30%) in comparison to untreated group (9.02 +/- 0.30%). The IC(50) of in vitro antiglycation and free radical scavenging activities of MA were 16.4 +/- 5.6 microg/ml and 61.7 +/- 2.1 microg/ml, respectively. These findings support that long-term administration of MA has antihyperglycemic, antioxidant and antiglycation effects in chronic diabetic rats, which may be beneficial as food supplement for diabetics.

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“…Furthermore the antioxidant activity of three different extracts of M. nigra fruits on haemoglobin glycosylation, peroxidative damage to human erythrocytes, liver hepatocytes of rats and human low-density lipoprotein (LDL) showed that black mulberry fruits inhibit haemoglobin glycosylation induced by glucose to differing degrees [23]. Hansawasdi and Kawabata [24] reported that flavonoid extracted from M. indica has an antidiabetic activity in experimental animals. However, few reports have evaluated the antidiabetic and hypoglycemic effects of whole mulberry fruits as a dietary supplement in animal models.…”

Section: Introductionmentioning

confidence: 99%

Hypoglycemic effect of white (Morus alba L.) and black (Morus nigra L.) mulberry fruits in diabetic rat

et al. 2014

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KEYWORDSThe aim of the present study was to investigate the hypoglycemic effect of white (Morus alba L.) and black (Morus nigra L.) mulberry fruits either used individually or in a combination on alloxan diabetic rats. These fruits are reported to be rich in antioxidants, flavonoids and phenolics that can potentially fight against diabetes mellitus. Male albino rats were divided into 5 groups: normal control, alloxan-diabetic control, diabetic rats treated with white mulberry fruit powder at 5% in the diet, diabetic rats treated with black mulberry fruit powder at 5% in the diet and diabetic rats treated with mixture of white and black mulberry fruits powder at 5% in the diet. After 4 weeks of treatment, blood glucose level, liver and kidney enzymes activity, lipid profile, lipid peroxidation and histopathological studies on liver, kidney and pancreas were evaluated. The mixture of white and black mulberry fruits showed the most significant (p < 0.05) improvement in feed efficiency ratio with increasing body weight gain, as well as decrease in blood glucose level and liver-kidney dysfunction when compared with diabetic control rats. Significant decrease in serum cholesterol, triglycerides and low density lipoprotein cholesterol (LDLc) as well as significant increase in high density lipoprotein cholesterol (HDLc) in diabetic rats was observed with all treatments. Moreover, mulberry fruits administration caused significant inhibition in lipid peroxidation and α-amylase activity. In addition, the beneficial effect of all treatments was further confirmed with histopathological examination of liver, kidney and pancreas. This study reveals hypoglycemic and hypolipidemic effects of white and black mulberry fruits either used individually or in combination as a dietary supplement in alloxan diabetic rats. Alloxan Antidiabetic Hypoglycemic Morus alba fruits Morus nigra fruits Lipid peroxidation

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α-Glucosidase inhibitory effect of mulberry (Morus alba) leaves on Caco-2

Cited by 108 publications

References 13 publications

Plants and Natural Compounds with Antidiabetic Action

Plants and Natural Compounds with Antidiabetic Action

Antihyperglycemic, Antioxidant and Antiglycation Activities of Mulberry Leaf Extract in Streptozotocin-Induced Chronic Diabetic Rats

Hypoglycemic effect of white (Morus alba L.) and black (Morus nigra L.) mulberry fruits in diabetic rat

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