α-Glucosidase inhibitory constituents from Chrozophora plicata

Tabussum, Asia; Riaz, Naheed; Saleem, Muhammad; Ashraf, Muhammad; Ahmad, Maqsood; Alam, Umber; Jabeen, Bushra; Malik, Abdul; Jabbar, Abdul

doi:10.1016/j.phytol.2013.08.005

Cited by 36 publications

(27 citation statements)

References 15 publications

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“…(30), and ninpogenin (31) isolated from the roots of Scrophularia ningpoensis exhibited moderate α-glucosidase inhibitory activity (IC 50 = 2.16 ± 0.13, 3.02 ± 0.16, 3.09 ± 0.16, and 1.54 ± 0.31 mmol/L, respectively) compared with acarbose (IC 50 = 0.37 ± 0.01 mM) [12].…”

Section: Terpenesmentioning

confidence: 99%

“…Four pyrole alkaloids, i.e., plicatanins A-D (89-92, respectively), were isolated from Chrozophora plicata, and showed inhibitory activity against yeast α-glucosidase with IC 50 values-202.3 ± 0.33, 178.62 ± 0.78, 27.85 ± 0.75, and 57.15 ± 0.44 mol/L, respectively; compound 91 showed the strongest inhibitory activity, which was stronger than that of acarbose (IC 50 = 38.25 ± 0.12 mol/L) [30].…”

Section: Alkaloidsmentioning

confidence: 99%

“…Two flavonoid compounds plicatanoside (247) and apigenin-5-O-β-D-glucopyranoside (248), isolated from C. plicata, showed inhibitory activity against yeast α-glucosidase (IC 50 = 111.23 ± 0.65 and 287.12 ± 0.75 mol/L, respectively), but the inhibition is not as strong as that of acarbose (IC 50 = 38.25 ± 0.12 mol/L) [30].…”

Section: Flavonoidsmentioning

confidence: 99%

“…Methyl p-coumarate (324) isolated from C. plicata showed yeast α-glucosidase inhibitory activity (IC 50 = 54.15 ± 0.005 mol/L), which was slightly weaker than that of acarbose (IC 50 = 38.25 ± 0.12 mol/L) [30].…”

Section: Phenylpropanoidsmentioning

confidence: 99%

“…β-Sitosterol (366) and β-sitosterol-3-O-β-D-glucopyranoside (367) isolated from C. plicata showed yeast α-glucosidase inhibitory activity (IC 50 = 277.7 ± 0.003 and 258.71 ± 0.07 mol/L), but the inhibitory activity was lower than that of acarbose (IC 50 = 38.25 ± 0.12 mol/L) [30].…”

Section: Steridesmentioning

confidence: 99%

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α-Glucosidase inhibitors isolated from medicinal plants

Yin

Zhang

Feng

et al. 2014

Food Science and Human Wellness

359

233

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Objective: α-Glucosidase inhibitors can be used as a new class of antidiabetic drug. By competitively inhibiting glycosidase activity, these inhibitors help to prevent the fast breakdown of sugars and thereby control the blood sugar level. This study provides a wealth of information about α-glucosidase inhibitors isolated from medicinal plants; this knowledge will be useful in finding more potent antidiabetic candidates from the natural resources for the clinical development of antidiabetic therapeutics. Results: 411 compounds exhibiting α-glucosidase inhibitory activity were summarized and isolated them from medicinal plants. The compound classes isolated include: terpenes (61) from 14 genus, alkaloids (37) from 11 genus, quinines (49) from 4 genus, flavonoids (103) from 24 genus, phenols (37) from 9 genus, phenylpropanoids (73) from 20 genus, sterides (8) from 5 genus, and other types of compounds (43). Conclusion: Compounds with α-glucosidase inhibitory activity are abundant in nature and can be obtained from several sources. They have high α-glucosidase inhibitory potential, and can be clinically developed for treating diabetes mellitus.

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Section: Terpenesmentioning

confidence: 99%

Section: Alkaloidsmentioning

confidence: 99%

Section: Flavonoidsmentioning

confidence: 99%

Section: Phenylpropanoidsmentioning

confidence: 99%

Section: Steridesmentioning

confidence: 99%

See 3 more Smart Citations

α-Glucosidase inhibitors isolated from medicinal plants

Yin

Zhang

Feng

et al. 2014

Food Science and Human Wellness

359

233

View full text Add to dashboard Cite

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Molecular Insight and Mode of Inhibition of α‐Glucosidase and α‐Amylase by Pahangensin A from Alpinia pahangensisRidl.

Loo

Leong

Sivasothy

et al. 2019

Chemistry & Biodiversity

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The inhibition of carbohydrate‐hydrolyzing enzymes in human digestive organs is crucial in controlling blood sugar levels, which is important in treating type 2 diabetes. In the current study, pahangensin A (1), a bis‐labdanic diterpene characterized previously in the rhizomes of Alpinia pahangensis Ridl., was identified as an active dual inhibitor for α‐amylase (IC50=114.80 μm) and α‐glucosidase (IC50=153.87 μm). This is the first report on the dual α‐amylase and α‐glucosidase inhibitory activities of a bis‐labdanic diterpene. The Lineweaver‐Burk plots of compound 1 indicate that it is a mixed‐type inhibitor with regard to both enzymes. Based on molecular docking studies, compound 1 docked in a non‐active site of both enzymes. The dual inhibitory activity of compound 1 makes it a suitable natural alternative in the treatment of type 2 diabetes.

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Advances in the natural α‐glucosidase inhibitors

Şöhretoğlu,

Renda,

Arroo

et al. 2023

eFood

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Abstractα‐Glucosidase (AG) inhibitors, one of the classes of oral antidiabetics used to treat type 2 diabetes mellitus, delay digestion and absorption of glucose, which in turn, has a lowering effect on postprandial blood glucose and insulin levels. Natural products are a great source for the development of new AG inhibitory drug candidates. We aim to summarize advances in natural AG inhibitors according to their secondary metabolite groups in the last decade. Their mechanisms of action and structure–activity relationships will especially be discussed.

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α-Glucosidase inhibitory constituents from Chrozophora plicata

Cited by 36 publications

References 15 publications

α-Glucosidase inhibitors isolated from medicinal plants

α-Glucosidase inhibitors isolated from medicinal plants

Molecular Insight and Mode of Inhibition of α‐Glucosidase and α‐Amylase by Pahangensin A from Alpinia pahangensisRidl.

Advances in the natural α‐glucosidase inhibitors

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