α –Glucosidase inhibitory activity of breadfruit leaf extract (Artocarpus altilis (parkinson) fosberg)

Rante, Herlina; Alam, Gemini; Irwan, Muhammad

doi:10.1088/1742-6596/1341/7/072015

Cited by 7 publications

(6 citation statements)

References 11 publications

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“…Similar results were also reported by Sikarwar et al (2015) where the only confirmed phytochemicals were flavonoids, steroids, tannins [15]. Among the five bioactive compounds that are expected to have analgesic properties confirmed to be present in breadfruit leaf extracts by many phytochemical determination studies are flavonoids [16,17].…”

Section: Treatments Parameterssupporting

confidence: 81%

Analgesic activity of the combined extract of sukun (Artocarpus altilis) and melinjo (Gnetum gnemon L.) Leaves in mice

Yusuf¹,

Wahidah²,

Widodo³

et al. 2020

GSC Biol. and Pharm. Sci.

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Analgesic is any drug used to achieve analgesia—relieve from pain, without blocking the conduction of nerve impulses. Sukun (Artocarpusaltilis) and melinjo (Gnetumgnemon L.) are plants that can be expected to have analgesic properties because they contain bioactive that can inhibit biosynthesis of prostaglandins, a hormone-like pain reducing agent. To determine analgesic effect of two plants in question, the combination extract of melinjo and sukun leaves were treated to mice by applying writhing test. Male mice (n=28) were grouped into seven consisted of two control groups (negative dan positive) and five test groups. The negative control group (KN) received CMC 0.5%, the positive control mice received 1.3 mg/kg BW mefenamic acid. Test groups were given leaf extracts of sukun and melinjo with the dose ratios (sukun : melinjo) as follows (200: 0), (150 : 50), (100 : 100 ), (50 : 150), and (0 : 200) mg/kg BW respectively. After 15 minutes all mice were pain-induced with 1% acetic acid intraperitoneally. Stretching activity of the animals was observed every 5 minutes for 1 hour. The result showed that the extracts with a dose ratio of (150 + 50) mg/kg BW has a comparable anlgesic effects to the mefenamic acid is the most effective combination among other comination doses.

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Section: Treatments Parameterssupporting

confidence: 81%

Analgesic activity of the combined extract of sukun (Artocarpus altilis) and melinjo (Gnetum gnemon L.) Leaves in mice

Yusuf¹,

Wahidah²,

Widodo³

et al. 2020

GSC Biol. and Pharm. Sci.

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“…Another plant species Artocarpus altilis, commonly referred to as breadfruit and classified under the Moraceae family, is recognized for its richness in carbohydrates and diverse beneficial properties including antibacterial, antitubercular, antiviral, antifungal, antiplatelet, anti-arthritis, and antidiabetic activities. Ethanolic extract of these plant leaves exhibited significant α-glucosidase inhibitory activity [52].…”

Section: Medicinal Plants With Anti-diabetic Potential Used In Tradit...mentioning

confidence: 99%

Exploring Folklore Ecuadorian Medicinal Plants and Their Bioactive Components Focusing on Antidiabetic Potential: An Overview

Bhattacharya,

Gupta,

Flekalová

et al. 2024

Preprint

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Diabetes mellitus (DM) is a metabolic disorder characterized by the deficiency of insulin production and is one of the concerning health problems worldwide, especially in developing countries. Considering the systemic toxicity associated with current antidiabetic medications and their limited efficacy, there is an urgent need to discover new plant-based natural antidiabetics. Since time immemorial, medicinal plants have played an important role in the management of health disorders. In recent years, herbal medicine has experienced exponential growth in popularity worldwide, owing to its natural origin and fewer side effects, appealing to both developing and developed nations. Ecuador has a rich cultural history in ethnobotany that plays a crucial role in their people's lives. Several Ecuadorian medicinal plants have hypoglycemic or an-ti-hyperglycemic properties that are rich with bioactive phytochemicals. These medicinal plants were extensively used in traditional medicine preparation in Ecuador for many decades to treat diabetes because of their cost-effectiveness, available traditional knowledge, and low toxicity. Many Ecuadorian medicinal plants are reported to have antidiabetic properties that reduce blood sugar levels, and oxidative stress, regulate intestinal function, improve insulin resistance, inhibit α-amylase and α-glucosidase, lower gluconeogenic enzymes, stimulate glucose uptake mechanisms, and play an important role in glucose and lipid metabolism, yet there is a substantial lack of integrated approach between the existing ethnomedicinal practice and pharmacological research. Therefore, this review aims to discuss and explore the traditional medicinal plants used in Ecuador for treating DM and their bioactive phytochemicals, which are mainly responsible for their anti-diabetic properties.

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“…Another plant species, Artocarpus altilis , commonly referred to as breadfruit and classified under the Moraceae family, is recognized for its richness in carbohydrates and diverse beneficial properties including antibacterial, antitubercular, antiviral, antifungal, antiplatelet, anti-arthritis, and antidiabetic activities. Methanolic extract showed α-glucosidase inhibitory activity with an IC 50 value of 40.9 μg/mL, whereas acarbose was used as a positive control with an IC 50 value of 964.6 μg/mL [ 26 , 52 ].…”

Section: Medicinal Plants With Antidiabetic Potential Used In the Tra...mentioning

confidence: 99%

Exploring Folklore Ecuadorian Medicinal Plants and Their Bioactive Components Focusing on Antidiabetic Potential: An Overview

Bhattacharya,

Gupta,

Flekalová

et al. 2024

Plants

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Diabetes mellitus (DM) is a global health concern characterized by a deficiency in insulin production. Considering the systemic toxicity and limited efficacy associated with current antidiabetic medications, there is the utmost need for natural, plant-based alternatives. Herbal medicines have experienced exponential growth in popularity globally in recent years for their natural origins and minimal side effects. Ecuador has a rich cultural history in ethnobotany that plays a crucial role in its people’s lives. This study identifies 27 Ecuadorian medicinal plants that are traditionally used for diabetes treatment and are prepared through infusion, decoction, or juice, or are ingested in their raw forms. Among them, 22 plants have demonstrated hypoglycemic or anti-hyperglycemic properties that are rich with bioactive phytochemicals, which was confirmed in several in vitro and in vivo studies. However, Bryophyllum gastonis-bonnieri, Costus villosissimus, Juglans neotropica, Pithecellobium excelsum, and Myroxylon peruiferum, which were extensively used in traditional medicine preparation in Ecuador for many decades to treat diabetes, are lacking in pharmacological elucidation. The Ecuadorian medicinal plants used to treat diabetes have been found to have several bioactive compounds such as flavonoids, phenolics, fatty acids, aldehydes, and terpenoids that are mainly responsible for reducing blood sugar levels and oxidative stress, regulating intestinal function, improving insulin resistance, inhibiting α-amylase and α-glucosidase, lowering gluconeogenic enzymes, stimulating glucose uptake mechanisms, and playing an important role in glucose and lipid metabolism. However, there is a substantial lack of integrated approaches between the existing ethnomedicinal practices and pharmacological research. Therefore, this review aims to discuss and explore the traditional medicinal plants used in Ecuador for treating DM and their bioactive phytochemicals, which are mainly responsible for their antidiabetic properties. We believe that the use of Ecuadorian herbal medicine in a scientifically sound way can substantially benefit the local economy and industries seeking natural products.

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α –Glucosidase inhibitory activity of breadfruit leaf extract (Artocarpus altilis (parkinson) fosberg)

Cited by 7 publications

References 11 publications

Analgesic activity of the combined extract of sukun (Artocarpus altilis) and melinjo (Gnetum gnemon L.) Leaves in mice

Analgesic activity of the combined extract of sukun (Artocarpus altilis) and melinjo (Gnetum gnemon L.) Leaves in mice

Exploring Folklore Ecuadorian Medicinal Plants and Their Bioactive Components Focusing on Antidiabetic Potential: An Overview

Exploring Folklore Ecuadorian Medicinal Plants and Their Bioactive Components Focusing on Antidiabetic Potential: An Overview

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