α-Glucosidase inhibitors from the leaves of Embelia ribes

Dang, Phu Hoang; Nguyen, Nhan Trung; Nguyen, Hai Xuan; Nguyen, Luan Bao; Le, Tho Huu; Do, Truong Nhat Van; Can, Mao Van; Nguyen, Mai Thanh

doi:10.1016/j.fitote.2014.12.004

Cited by 31 publications

(12 citation statements)

References 24 publications

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“…Among isolated compounds, 2, 5, 6, 7 and 8 displayed strong inhibition with the IC 50 values in the range of 1.319.3 M. Reports showed that flavones with a hydroxy group at C-3′ possessed stronger inhibition than the corresponding ones without a C-3′ hydroxy group [14] explaining the α-glucosidase inhibitory activity of myricetin (2) is stronger nearly 140 times than that of quercetin (3). Moreover, the appearance of C-3 hydroxy group also played an important role in the above-mentioned activity [15] which is in accordance with the low inhibition of myricetin 3-O-α-L-rhamnoside (4) compared to those of its aglycon, myricetin (2) and quercetin (3).…”

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confidence: 99%

A New Glycoside and in vitro Evalution of α-Glucosidase Inhibitory Activity of Constituents of the Mangrove Lumnitzera racemosa

Phương¹,

Thuy

Đức³

et al. 2017

Natural Product Communications

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From Lumnitzera racemosa Willd., a new glycoside, 2-O-galloyl-α-L-rhamnopyranosyl-(34)-3-O-galloyl-α-L-rhamnopyranose (1), as well as nine known compounds were isolated. Their chemical structures were elucidated by spectroscopic data analysis as well as comparison with the ones in the literature. The evaluation of α-glucosidase inhibitory activity of the extracts and some isolated compounds was measured.

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mentioning

confidence: 99%

A New Glycoside and in vitro Evalution of α-Glucosidase Inhibitory Activity of Constituents of the Mangrove Lumnitzera racemosa

Phương¹,

Thuy

Đức³

et al. 2017

Natural Product Communications

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“…The a-glucosidase inhibition potential of T. jasminoides extracts were determined according to the modified methods of previous reports [24,25]. Briefly, 50 lL of diluted sample, 50 lL of phosphate buffer (0.1 mmol/L, pH 6.9) and 100 lL a-glucosidase solution (0.1 U/mL, in 0.1 mol/L phosphate buffer, pH 6.9) were incubated in 96-well plates at 25 C for 10 min.…”

Section: A-glucosidase Inhibitory Assaymentioning

confidence: 99%

Cytotoxic activities against MCF-7 and MDA-MB-231, antioxidant andα-glucosidase inhibitory activities ofTrachelospermum jasminoidesextractsin vitro

Song

Zhang

Gong

et al. 2019

Biotechnology & Biotechnological Equipment

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The present study investigated the cytotoxic activities against MCF-7 and MDA-MB-231 cells, and the potential antioxidant and a-glucosidase inhibitory activities of the extracts of the aerial parts of Trachelospermum jasminoides, a traditional medicinal plant used for the treatment of rheumatic arthralgia in China. In MTT assay and microscopic analysis, the ethyl acetate extract (EAE) of T. jasminoides showed moderate cytotoxic effect against MCF-7 and MDA-MB-231 with IC 50 values of 109.54 ± 2.39 lg/mL and 162.68 ± 9.52 lg/mL, respectively, but the water extract (WE) was inactive against both of them. With gallic acid and rutine as equivalents for determination, the total phenolic and total flavonoid contents in the EAE (54.93 ± 0.32 mg GAE/g and 186.75 ± 4.55 mg RE/ g, respectively) were higher than those of the WE. The antioxidant activities of the EAE and WE, which were evaluated by reducing power assay, DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging assay and hydroxyl radical scavenging assay, may be directly associated with the high contents of phenols and flavonoids in T. jasminoides. The EAE showed higher inhibitory effect in the a-glucosidase inhibition tests with an IC 50 value of 776.81 ± 107.80 lg/mL as compared to the WE with 2607.48 ± 364.31 lg/mL. Furthermore, the antioxidant activity and the inhibitory effects of the fractions against a-glucosidase were concentration-dependent. ARTICLE HISTORY

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“…Khi mẫu thử có hoạt chất ức chế enzyme α-glucosidase thì hàm lượng pnitrophenol tạo thành sẽ giảm. So sánh cường độ màu của dung dịch khi có và không có hoạt chất ức chế, sẽ tính được khả năng ức chế enzyme α-glucosidase của hoạt chất đó [8][9] (Hình 1).…”

Section: Phương Pháp Thử Hoạt Tính ứC Chế Enzyme αGlucosidaseunclassified

“…Để có cơ sở đánh giá hoạt tính của những mẫu chất khảo sát, chúng tôi sử dụng acarbose làm chất đối chứng dương để so sánh, vì đây là hợp chất được sử dụng làm chất đối chứng trong các tài liệu tham khảo [8][9] (Hình 2). Dựa trên phần trăm ức chế tại các nồng độ khác nhau của mẫu thử, tiến hành đánh giá khả năng ức chế enzyme α-glucosidase của mẫu thử thông qua giá trị IC50.…”

Section: Phương Pháp Thử Hoạt Tính ứC Chế Enzyme αGlucosidaseunclassified

Study on structure–activity relationships (SARs) of epoxylignan compounds with α- glucosidase inhibitory activity

Nguyen

2018

Sci. Tech. Dev. J. - Nat. Sci.

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Epoxylignans are polyphenolic compounds, which possess various biological activities such as antiproliferative activity on cancer cells, antioxidant, antihyperglycemic,… In this research, we study on α- glucosidase inhibitory activity of 11 epoxylignans isolated from the stem of Artocarpus heterophyllus, the stem of Willughbeia cochinchinensis, the stem bark of Crateva religiosa, and the propolis of Trigona minor. The results showed that, compounds 1–4 and 7–10 were more potent inhibitory activity than that of positive control acarbose (IC50, 214.5 µM). Based on the results, their structure-activity relationships showed that the presence of the hydroxyl group at C-4, and C-4ʹ positions play an important role in increasing the activity. Furthermore, diepoxylignans having a ketone group at C-9′ exhibited stronger activity. In contrast, the opening of an epoxy ring at C-7 the C-9′ positions reduced the activity.

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α-Glucosidase inhibitors from the leaves of Embelia ribes

Cited by 31 publications

References 24 publications

A New Glycoside and in vitro Evalution of α-Glucosidase Inhibitory Activity of Constituents of the Mangrove Lumnitzera racemosa

A New Glycoside and in vitro Evalution of α-Glucosidase Inhibitory Activity of Constituents of the Mangrove Lumnitzera racemosa

Cytotoxic activities against MCF-7 and MDA-MB-231, antioxidant andα-glucosidase inhibitory activities ofTrachelospermum jasminoidesextractsin vitro

Study on structure–activity relationships (SARs) of epoxylignan compounds with α- glucosidase inhibitory activity

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