α-Fetoprotein–producing gastric cancer: histochemical analysis of cell proliferation, apoptosis, and angiogenesis

Koide, Naoki; Nishio, Akira; Igarashi, Jun; Kajikawa, Shoji; Adachi, Wataru; Amano, Jun

doi:10.1016/s0002-9270(99)00214-2

Cited by 66 publications

(39 citation statements)

References 20 publications

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“…The best combination of tumor markers was CA 72-4 and CA 19-9 (56.8%), which was similar to that of a previous report 23 . None of the patients were positive for AFP; the positivity of AFP in gastric cancer has been reported to be low (15%) 24 , and usually, AFP has been a marker of aggressive behavior tumor and poor prognosis 15 .…”

Section: Discussionmentioning

confidence: 90%

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Preoperative serum levels of ca 72-4, cea, ca 19-9, and Alpha-fetoprotein in patients with gastric cancer

et al. 2002

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INTRODUCTION: The clinical importance of preoperative serum levels of CA 72-4, carcinoembryonic antigen (CEA), CA 19-9, and alpha-fetoprotein (AFP) was prospectively evaluated in 44 patients with gastric cancer. METHOD: The serum tumor marker levels were determined by commercial radioimmunoassay kits. Positivity for CA 72-4 (>4 U/mL), CEA (>5 ng/mL), CA 19-9 (>37 U/mL), and AFP (>10 ng/mL) were correlated according to the stage, histology, and lymph node metastasis. RESULTS AND DISCUSSION: CA 72-4 showed a higher positivity rate for gastric cancer (47.7%) than CEA (25%), CA 19-9 (25%), and AFP (0%). The combination of CA 72-4 with CEA and CA 19-9 increased the sensitivity to 61.4%. The positivity rates of CA 72-4 in patients at stages I and II (initial disease) and in patients at stages III and IV (advanced disease) were 9% and 60.6%, respectively (P < 0.005). No correlation was found between CEA and CA 19-9 levels and the stage of gastric cancer. There was a tendency of positivity for CA 72-4 to suggest lymph node involvement, but it was not significant (P = 0.075). Serum levels of tumor markers did not show a correlation with the histological types of gastric cancer. CONCLUSION: Preoperative serum levels of CA 72-4 provided a predictive value in indicating advanced gastric cancer.

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Section: Discussionmentioning

confidence: 90%

“…These biological characteristics of AFP-producing gastric cancer reflect the aggressive behavior of the tumor and the poor prognosis of patients with this type of cancer 15 .…”

Section: Methodmentioning

confidence: 99%

Preoperative serum levels of ca 72-4, cea, ca 19-9, and Alpha-fetoprotein in patients with gastric cancer

et al. 2002

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“…In addition, Koide et al [66] have reported that AFP-producing gastric cancer has high proliferative activity, weak apoptosis, and rich neovascularization. Compared with findings in previous reports [66,67], Ki-67 expression-which is associated with proliferative activity and tumor progression [68]was extremely marked in our patient. Furthermore, these tumors are known to be resistant to chemotherapy [69].…”

Section: Discussionmentioning

confidence: 99%

Hepatoid adenocarcinoma of the stomach

et al. 2001

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“…AFP-producing gastric carcinomas have a higher malignant potential including higher proliferative activity, reduced apoptosis, and more neovascularization than AFP-negative gastric carcinomas. These biological characteristics of AFP-producing gastric carcinomas result in aggressive behavior and a poor prognosis [19]. In addition, increased c-Met expression contributes to the poor prognosis of patients with AFP-producing gastric carcinoma [20].…”

Section: Discussionmentioning

confidence: 99%

A Case of Alpha-fetoprotein and Des-gamma-carboxy Prothrombin-Producing Gastric Carcinoma Mimicking Hepatocellular Carcinoma

Hotta¹,

Kashiwabara²,

Arai³

et al. 2016

Int J Gastroenterol Disord Ther

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α-Fetoprotein–producing gastric cancer: histochemical analysis of cell proliferation, apoptosis, and angiogenesis

Cited by 66 publications

References 20 publications

Preoperative serum levels of ca 72-4, cea, ca 19-9, and Alpha-fetoprotein in patients with gastric cancer

Preoperative serum levels of ca 72-4, cea, ca 19-9, and Alpha-fetoprotein in patients with gastric cancer

Hepatoid adenocarcinoma of the stomach

A Case of Alpha-fetoprotein and Des-gamma-carboxy Prothrombin-Producing Gastric Carcinoma Mimicking Hepatocellular Carcinoma

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