Preoperative serum levels of ca 72-4, cea, ca 19-9, and Alpha-fetoprotein in patients with gastric cancer

Abstract

INTRODUCTION: The clinical importance of preoperative serum levels of CA 72-4, carcinoembryonic antigen (CEA), CA 19-9, and alpha-fetoprotein (AFP) was prospectively evaluated in 44 patients with gastric cancer. METHOD: The serum tumor marker levels were determined by commercial radioimmunoassay kits. Positivity for CA 72-4 (>4 U/mL), CEA (>5 ng/mL), CA 19-9 (>37 U/mL), and AFP (>10 ng/mL) were correlated according to the stage, histology, and lymph node metastasis. RESULTS AND DISCUSSION: CA 72-4 showed a higher positivity rate for gastric cancer (47.7%) than CEA (25%), CA 19-9 (25%), and AFP (0%). The combination of CA 72-4 with CEA and CA 19-9 increased the sensitivity to 61.4%. The positivity rates of CA 72-4 in patients at stages I and II (initial disease) and in patients at stages III and IV (advanced disease) were 9% and 60.6%, respectively (P < 0.005). No correlation was found between CEA and CA 19-9 levels and the stage of gastric cancer. There was a tendency of positivity for CA 72-4 to suggest lymph node involvement, but it was not significant (P = 0.075). Serum levels of tumor markers did not show a correlation with the histological types of gastric cancer. CONCLUSION: Preoperative serum levels of CA 72-4 provided a predictive value in indicating advanced gastric cancer.

Discrimination of Breast Cancer by Anti-Malignin Antibody Serum Test in Women Undergoing Biopsy

“…To conclude, we found that AMAS testing discrimination of neoplasia was significantly different from random, with sensitivities and specificities similar to other clinical tests such as prostate-specific antigen (29) and carcinoembryonic antigen (30)(31)(32). However, in middle-aged women with a breast finding suspicious for cancer, the test was insufficiently sensitive to allow a confident decision for or against biopsy, and falsepositive rates were too high for screening of low-risk populations.…”

Clinical significance of serum tumor markers for gastric cancer: a systematic review of literature by the Task Force of the Japanese Gastric Cancer Association

“…Elevated CA72-4 was associated with tumor depth [28,37,43], nodal involvement [10,12,20,24,28,34,37,42,43], peritoneal metastases [10,24,34,43], distant metastases [34,43], and stage [9,20,28,34,35,39,42,43]. Ucar et al [43] reported that 9 of 11 patients (82 %) with liver metastases were positive for CA72-4.…”

Relationship of clinicopathological parameters and preoperative CA19-9 level in patients with gastric cancer

“…However, Guadagni et al 26 found no association between serosa involvement and elevated sera CA 19-9 levels. Early and advanced stages of GC confirmed after surgery based on positive or negative levels of CA 19.9 and their association with staging in Table V showed that when patients in stages early (I-II) and advanced (III-IV) were compared, significant difference was not observed for CA 19.9 (P=0.4).…”