α-Aminophosphinic Acids and α-Aminophosphine Oxides. I. Alkyl-α-aminoalkylphosphinic Acids, α-Aminoalkyl(aryl)phosphinic Acids, and α-Aminoalkyl(diaryl)phosphine Oxides

Advances in the Chemistry of Aminophosphinic Acids

“…Reaction of N-bromomethyl-phthalimide 12 with phosphonites 13 gave the phosphinates 14 in high yields (66 to 94%), 69 but reaction of N-a-chloroethyl-phthalimide with dimethyl-phenylphosphonite proved less satisfactory. In this case only a 5% yield of the phosphinate 17 was obtained.…”

.alpha.-Aminophosphinic acids and .alpha.-aminophosphine oxides. Carbamoyl(methyl)phosphinic acid, carbamoyl(phenyl)phosphinic acid, and carbamoyl(diphenyl)phosphine oxide

“…Our study of a-aminoalkylphosphinic acids and -aminoalkylphosphine oxides (6) was extended to carbamylphosphinic acids and carbamylphosphine oxides.…”

Michaelis-Arbuzov-Type Reaction of 1-Imidoalkyltriarylphosphonium Salts with Selected Phosphorus Nucleophiles

“…The synthesis of 1-imidoalkylphosphonates, 1-imidoalkylphosphinates, and 1-imidoalkylphosphine oxides described in the literature are mainly based on the Michaelis-Arbuzov- or Michaelis-Becker-type reaction of the corresponding halides with phosphorus nucleophiles, and in most cases, they are related to the simplest derivatives ( 1 , R 1 = H; I and II, Scheme 1) [15,19,22,23,24,25,26,27,28,29]. Other known methods are rather labor consuming and require more sophisticated substrates such as 1-hydroxyalkylphosphonates [30] or silyl compounds [31] (Scheme 1, I, path D and E), which limits the structural diversity of the products obtained.…”