α-adrenoceptor antagonistic and calcium antagonistic effects of nicergoline in the rat isolated aorta

Heitz, Christiane; Descombes, Jean-Jacques; Miller, Robert C.; Stoclet, Jean‐Claude

doi:10.1016/0014-2999(86)90669-2

Cited by 23 publications

(7 citation statements)

References 18 publications

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“…Moreover, those studies emphasized the critical importance of such a threshold in this model, w hich means that small chang es in regional CBF can translate to much larger effects in outcome. Nicergoline is an alpha-adrenergic receptor blocking agent, w hich affects CBF by reducing cerebrovascular resistance (Heitz et al 1986). Using 2 types of models of rat MCA occlusion, w e also demonstrated that pretreatment w ith nicergoline increased CBF levels after ischemia and prevented brain damage.…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective effects of the ergoline derivative nicergoline following transient and permanent focal cerebral ischemia in rats

Nito¹,

Nishiyama²,

Saito³

et al. 2015

J Exp Stroke Transl Med

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Section: Discussionmentioning

confidence: 99%

Neuroprotective effects of the ergoline derivative nicergoline following transient and permanent focal cerebral ischemia in rats

Nito¹,

Nishiyama²,

Saito³

et al. 2015

J Exp Stroke Transl Med

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“…These may link adipose-derived NGF to the pathophysiology of both cardiometabolic and neuropsychiatric diseases (54,55). Interestingly, treatment with nicergoline, an ergot alkaloid derivative with α 1 -adrenoreceptor-blocking and calcium antagonistic properties (56), has been shown to elevate the cerebral blood flow and improve the hemodynamics in aged rats with cerebral ischemia (57). These effects appear to be linked to the nicergoline-induced NGF enhancement in the aged rat brain (58).…”

Section: Functions and Therapeutic Potentials Of Ngfmentioning

confidence: 99%

The endocannabinoid system: critical for the neurotrophic action of psychotropic drugs

Hassanzadeh

2010

Biomedical Reviews

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There is growing evidence that neurotrophins besides their well-established actions in regulating the survival, differentiation, and maintenance of the functions of specific populations of neurons, act as the potential mediators of antidepressant responses. Previous studies on the regulation of nerve growth factor (NGF) levels by psychotropic medications are limited in scope and the underlying mechanism(s) remain elusive. In this review, the latest findings on the effects of pharmacologically heterogeneous groups of psychotropic drugs on NGF contents in the brain regions involved in the modulation of emotions are summarized. Moreover, the therapeutic potentials of the endocannabinoid system which is linked to depression and/or antidepressant effects and appears to interact with neurotrophin signalling, are reviewed. New findings demonstrate that endocannabinoid system is involved in the mechanisms of action of certain psychotropic medications including neurokinin receptor antagonists and that these are mediated via the upregulation of brain regional levels of NGF. This provides a better understanding of the pathophysiological mechanisms underlying neuropsychiatric disorders, leading to novel drug designs.

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“…15) Nicergoline, a derivative of ergot alkaloid, is an ameliorator of cerebral circulation and metabolism. [16][17][18][19][20][21][22][23][24] In addition to enhancement of cholinergic [25][26][27][28] and dopaminergic transmissions in the brain, 29) protective actions of nicergoline against anoxic and/or ischemic brain damage and neuronal cell death are reported in several cerebral ischemic animals. [18][19][20]30) A recent study showed the neuroprotective action and the reduction of [Glu] o by nicergoline in ischemic rat brains.…”

Section: Glutamate Transporters Limit the Extracellular Concentrationmentioning

confidence: 99%

Nicergoline Enhances Glutamate Uptake via Glutamate Transporters in Rat Cortical Synaptosomes

Nishida

Iwata²,

Kudo

et al. 2004

Biological & Pharmaceutical Bulletin

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To elucidate the mechanisms of neuroprotective action of nicergoline, we examined its effect on glutamate transport in rat cortical synaptosomes and cloned glutamate transporters. In synaptosomes, nicergoline enhanced the glutamate uptake at 1-10 m mM in standard medium and suppressed the increase of extracellular glutamate by reversed transport in low Na ؉ medium. Apparent increase of extracellular glutamate concentration by dihydrokinate, an inhibitor of glial glutamate transporter GLT-1, was antagonized by nicergoline. In Xenopus oocytes expressing mouse neuronal glutamate transporter (mEAAC1), the glutamate-induced inward current was enhanced by nicergoline. These results suggest that nicergoline reduces the extracellular glutamate concentration through its effect on glutamate transporters.

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α-adrenoceptor antagonistic and calcium antagonistic effects of nicergoline in the rat isolated aorta

Cited by 23 publications

References 18 publications

Neuroprotective effects of the ergoline derivative nicergoline following transient and permanent focal cerebral ischemia in rats

Neuroprotective effects of the ergoline derivative nicergoline following transient and permanent focal cerebral ischemia in rats

The endocannabinoid system: critical for the neurotrophic action of psychotropic drugs

Nicergoline Enhances Glutamate Uptake via Glutamate Transporters in Rat Cortical Synaptosomes

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