Zur Verbesserung der Ergebnisse bei der i.v. Pyelographie

Zinner, G

doi:10.1055/s-0029-1227377

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1974

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“…In this way unpleasant side effects are supposed to be rarer than after slow injection of the same dose [6,13,15,42,60,[87][88][89]. This is even true for the old pyridones, which are no longer in clinical use because of their toxic side effects [1].…”

Section: Discussionmentioning

confidence: 99%

Contrast media as histamine liberators in man

1974

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6 minutes after Joduron | 70% (0.5 ml/kg), Biligrafin | 30% (0.4 ml/kg), Urografin | 60% (0.5 ml/kg), Urovison | 58% (0.5 ml/kg), Urovist | 65% (0.75 ml/kg) and Conray | 70% (0.5 ml/kg) (within 1 minute injected) the level of circulating histamine in plasma is increased from less than 1.0 ng/ml to 2.0-2.5 ng/ml. The elevated levels return to normal within 20 minutes, in the case of Joduron | 70% and Biligrafin | 30% slower than after the other contrast media. Urivison | 30%, infused over 4 minutes (total dose 4 ml/kg), as dextrose 50%-solution (0.5 ml/kg) failed to change histamine concentration in plasma. Obviously the histamine liberating effect of the contrast media is a specific effect of these agents.

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Section: Discussionmentioning

confidence: 99%