Zur Ultrastruktur des Lungentumors der Maus

Klärner, Paul; Gieseking, R

doi:10.1007/bf00524273

Cited by 18 publications

(3 citation statements)

References 17 publications

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“…A discussion on the development and significance of these lamellar bodies is beyond the aim of the present paper. They are, anyway, peculiar to granular pneumocytes (or type B or type II alveolar cells) and their presence in neoplastic cells has been regarded as ultrastructural evidence of the alveolar origin of both human and animal lung tumours (Klarner and Gieseking, 1960;Nagaishi et al, 1965;Hattori et al, 1967;Brooks, 1968;Adamson et al, 1969;Flaks and Flaks, 1969;Johnston et al, 1971;Nisbet et al, 1971;Nash et al, 1972 Adamson et al (1969), Coalson et al (1970, and Nash et al (1972), but not by Geller and Toker (1969), and Razzuk et al (1970).…”

Section: Light Microscopymentioning

confidence: 99%

Human Peripheral Lung Tumours: Light and Electron Microscopic Correlation

Mollo¹,

Canese²,

Campobasso³

1973

Br J Cancer

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Thirteen human peripheral lung tumours have been studied in both light and electron microscopy. They were classified as epidermoid carcinoma, mucus-secreting cell adenocarcinoma, and alveolar cell adenocarcinoma, the latter made up of granular pneumocytes. Alveolar cell cancer, as defined by ultrastructural features, could assume different gross histological patterns in light microscopy, and therefore electron microscopy is required for its identification. Since neither squamous nor mucous metaplasia was observed in any alveolar cell tumour, it is tentatively suggested that all peripheral lung tumours which lack these features may be derived from granular pneumocytes, irrespective of whether they appear to be adenocarcinomata or large cell carcinomata when examined by light microscopy. Images Fig. 1 Fig. 2 Fig. 3 Fig. 4 Fig. 5 Fig. 6 Fig. 7 Fig. 8 Fig. 9 Fig. 10 Fig. 11 Fig. 12 Fig. 13 Fig. 14

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Section: Light Microscopymentioning

confidence: 99%

Human Peripheral Lung Tumours: Light and Electron Microscopic Correlation

Mollo¹,

Canese²,

Campobasso³

1973

Br J Cancer

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“…These lamellar bodies closely resembled those found in the tumour cells (Fig. 7) might also develop from the epithelium of peripheral bronchi and that pulmonary neoplasms composed of such cells may not necessarily derive from the alveolar epithelium as postulated by Klarner and Gieseking (1960). This seems less surprising if one considers that both alveolar and bronchial epithelial cells originate from the same embryological columnar epithelium (Campiche et al, 1963;O'Hare and Sheridan, 1970;Hage, 1973).…”

mentioning

confidence: 55%

The ultrastructure of N-dibutylnitrosamine induced pulmonary tumours (adenocarcinomata) in European hamsters

Reznik-Schüller¹,

Möhr²

1975

Br J Cancer

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Summary.-N-dibutyl-nitrosamine induced pulmonary adenocarcinomata in European hamsters were studied electron microscopically. The tumours were composed of light and dark cells, which, due to their lamellar bodies, resembled alveolar epithelial cells Type II. As cells containing lamellar bodies also occasionally occurred with the epithelial lining of tumour associated peripheral bronchi, a possible bronchiolar origin of the neoplasms is discussed.RECENT studies have demonstrated the organotropic effects of N-dibutylnitrosamine for the respiratory tract and urinary bladder of the European hamster (Althoff et al., 1974). In the lungs, the majority of the neoplasms were mixed carcinomata and adenocarcinomata. As the tissue of origin could not be clarified for the tumours through routine histological methods, electron microscopical examination of lung tumours was performed for a small number of animals to elucidate more detail concerning the histogenesis of DBN induced lung cancer in this hamster species. The tumour parts not excised for electron microscopic examination were post-fixed in 4% buffered formalin and embedded in paraplast. Haematoxylin and eosin, PAS and Alcian blue stained sections were prepared for routine histological examinations. RESULTSThe 2 males appeared moribund and were killed after 57 and 59 weeks and the 2

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“…These authors also described the occurrence of peculiar intranuclear inclusions in some of the neoplastic type-I1 alveolar cells in all three cases studied. Svoboda (1962Svoboda ( , 1964, Klarner and Gieseking (1960) and Okada, Daido and Ishiko (1962) reported the electron-microscope findings in lung adenomata in mice, and agreed that there was an ultrastructural similarity between the adenoma cells and the alveolar epithelium that suggested that these tumours arise from alveolar epithelium. Brooks (1968) also stated that the mouse lung adenoma is derived from the type-B alveolar cell.…”

mentioning

confidence: 94%