Human Peripheral Lung Tumours: Light and Electron Microscopic Correlation

Abstract

Thirteen human peripheral lung tumours have been studied in both light and electron microscopy. They were classified as epidermoid carcinoma, mucus-secreting cell adenocarcinoma, and alveolar cell adenocarcinoma, the latter made up of granular pneumocytes. Alveolar cell cancer, as defined by ultrastructural features, could assume different gross histological patterns in light microscopy, and therefore electron microscopy is required for its identification. Since neither squamous nor mucous metaplasia was observed in any alveolar cell tumour, it is tentatively suggested that all peripheral lung tumours which lack these features may be derived from granular pneumocytes, irrespective of whether they appear to be adenocarcinomata or large cell carcinomata when examined by light microscopy. Images Fig. 1 Fig. 2 Fig. 3 Fig. 4 Fig. 5 Fig. 6 Fig. 7 Fig. 8 Fig. 9 Fig. 10 Fig. 11 Fig. 12 Fig. 13 Fig. 14

Survival Rates of Lung Cancer According to Histological Type

“…Such favourable behaviour could not be confirmed in the present or in other series (Hukill and Stern, 1962;Bennet and Sasser, 1969). On the other hand, the validity of alveolar cell cancer as a clinicopathological entity has been denied by Bennet and Sasser (1969) and recent ultrastructural observations in this Institute (Mollo, Canese and Campobasso, 1973) (Campobasso, 1968).…”

In vitro irradiation system for radiobiological experiments

“…In addition, ultrastructural electron microscopy analysis revealed features present in human lung tissue, such as desmosomes, confirming what hematoxylin and eosin staining had highlighted, and lipid clusters [11-13] (Figure 7a,b). Such structures were not observed in monolayer cultures of established tumor cell lines, as confirmed by the electron microscopy image of monolayer CAEP cells that showed polygonal shaped cells with no detectable desmosomes and only a few lipid clusters in the cytoplasm (Figure 7c).…”

Problematik der histologischen Klassifikation des Bronchialkarzinoms

“…A denokarzinom e sind histologisch gekennzeichnet durch den Bald, 1957;Fasske, 1970;Schubert, 1975;Müller, 1976 (Nash et al, 1972;Kuhn, 1972;Mollo et al, 1973;Greenberg et al, 1975 (Schubert, 1975;WHO, 1977 u.a.). …”