Zur Technik langfristiger Stoffwechselversuche an wachsenden Schweinen

Farries, Friedrich-Eberhard; Oslage, Hans Joachim

doi:10.1111/j.1439-0396.1961.tb00445.x

Cited by 21 publications

(1 citation statement)

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“…The pigs had an average initial weight of 25.8 ± 3.7 kg (means ± SD) and were fed restrictively with 2 single portions of 700 g per day, mixed with water and provided as mash. All barrows were housed in individual floor pens during the first 21 days of the trial and subsequently transferred into individual metabolism crates (described in [ 63 ]) until Day 29.…”

Section: Methodsmentioning

confidence: 99%

Metabolic and Hematological Consequences of Dietary Deoxynivalenol Interacting with Systemic Escherichia coli Lipopolysaccharide

Bannert

Tesch

Kluess

et al. 2015

Toxins

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Previous studies have shown that chronic oral deoxynivalenol (DON) exposure modulated Escherichia coli lipopolysaccharide (LPS)-induced systemic inflammation, whereby the liver was suspected to play an important role. Thus, a total of 41 barrows was fed one of two maize-based diets, either a DON-diet (4.59 mg DON/kg feed, n = 19) or a control diet (CON, n = 22). Pigs were equipped with indwelling catheters for pre- or post-hepatic (portal vs. jugular catheter) infusion of either control (0.9% NaCl) or LPS (7.5 µg/kg BW) for 1h and frequent blood sampling. This design yielded six groups: CON_CONjugular-CONportal, CON_CONjugular-LPSportal, CON_LPSjugular-CONportal, DON_CONjugular-CONportal, DON_CONjugular-LPSportal and DON_LPSjugular-CONportal. Blood samples were analyzed for blood gases, electrolytes, glucose, pH, lactate and red hemogram. The red hemogram and electrolytes were not affected by DON and LPS. DON-feeding solely decreased portal glucose uptake (p < 0.05). LPS-decreased partial oxygen pressure (pO2) overall (p < 0.05), but reduced pCO2 only in arterial blood, and DON had no effect on either. Irrespective of catheter localization, LPS decreased pH and base-excess (p < 0.01), but increased lactate and anion-gap (p < 0.01), indicating an emerging lactic acidosis. Lactic acidosis was more pronounced in the group DON_LPSjugular-CONportal than in CON-fed counterparts (p < 0.05). DON-feeding aggravated the porcine acid-base balance in response to a subsequent immunostimulus dependent on its exposure site (pre- or post-hepatic).

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Section: Methodsmentioning

confidence: 99%

Metabolic and Hematological Consequences of Dietary Deoxynivalenol Interacting with Systemic Escherichia coli Lipopolysaccharide

Bannert

Tesch

Kluess

et al. 2015

Toxins

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Lipopolysaccharides (LPS) modulate the metabolism of deoxynivalenol (DON) in the pig

et al. 2014

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Pigs might be exposed to lipopolysaccharides (LPS) and deoxynivalenol (DON) at the same time, and both toxins are thought to interactively affect the intestinal barrier, the innate immune system, and the xenobiotics metabolism. Hence, we aimed at examining the single and combined effects of both toxins on nutrient digestibility and DON metabolism. For this purpose, barrows (26 ± 4 kg) were fed restrictedly either a control diet (CON) or a diet contaminated with 3.1 mg DON/kg (DON) for 37 days. At day 37 of the experiment, pigs were infused intravenously for 60 min either with 100 μg DON/kg body weight (BW) (CON-DON), 7.5 μg LPS/kg BW (CON-LPS, DON-LPS) or a combination of both substances (CON-DON + LPS), or physiological saline (CON-CON, DON-CON). Blood samples were collected frequently until 3.25 h before the pigs were sacrificed for bile, liver, and kidney collection. The apparent digestibility of N-free extractives was significantly increased by 1 % when the DON-contaminated diet was fed. The total DON content in blood was significantly higher in endotoxemic pigs (34.8 ng/mL; CON-DON + LPS) when compared to the pigs infused with DON alone (18.8 ng/mL; CON-DON) while bile concentrations were not influenced by LPS. DON residue levels in liver and kidney closely reflected the treatment effects as described for blood. In contrast to DON infusion, the LPS challenge resulted in a significantly lower total DON concentration (13.2 vs. 7.5 ng/mL in groups DON-CON and DON-LPS, respectively) when the pigs were exposed to DON through the diet. The conjugation degree for DON in blood and bile was not influenced by treatments. In conclusion, endotoxemic pigs are characterized by higher DON residue levels in blood, liver, and kidney, probably by a compromised elimination.

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On the effectiveness of a detoxifying agent in preventing fusario-toxicosis in fattening pigs

Dänicke¹,

Valenta²,

Döll³

et al. 2004

Animal Feed Science and Technology

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Zur Technik langfristiger Stoffwechselversuche an wachsenden Schweinen

Cited by 21 publications

References 0 publications

Metabolic and Hematological Consequences of Dietary Deoxynivalenol Interacting with Systemic Escherichia coli Lipopolysaccharide

Metabolic and Hematological Consequences of Dietary Deoxynivalenol Interacting with Systemic Escherichia coli Lipopolysaccharide

Lipopolysaccharides (LPS) modulate the metabolism of deoxynivalenol (DON) in the pig

On the effectiveness of a detoxifying agent in preventing fusario-toxicosis in fattening pigs

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