Zur Stellung des Butansultamderivates Ospolot in der Behandlung zerebraler Anfallsleiden

F, Fluegel; Bente, D; Itil, T

doi:10.1055/s-0028-1112718

Cited by 26 publications

(3 citation statements)

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“…Together with slight paresthesias noted by some of the volunteers and patients, the side effects are the same as those encountered with the use of sulthiam. 3 All are considered a consequence of the known acidotic effects of carbonic anhydrase inhibitory activity. The only other effect observed was an asymptomatic decrease in the secretion of hydrochloric acid from the gastric mucosa.…”

Section: Discussionmentioning

confidence: 99%

Early human studies of a new carbonic anhydrase inhibitor (NSD 3004) with anticonvulsant properties

Lund¹,

Pedersen²,

Olsen³

et al. 1971

Clin Pharma and Therapeutics

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Section: Discussionmentioning

confidence: 99%

Early human studies of a new carbonic anhydrase inhibitor (NSD 3004) with anticonvulsant properties

Lund¹,

Pedersen²,

Olsen³

et al. 1971

Clin Pharma and Therapeutics

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“…Tachypnoea occurred in a few cases in patients taking more than 0.6 g daily. Flugel et al (3) note that this side effect tended to occur especially in temporal lobe cases. Raffauf (6) reported 3 cases of status epilepticus occurring in a group of 32 patients treated exclusively with sulthiame.…”

Section: Introductionmentioning

confidence: 97%

“…In the first clinical reports of its therapeutic effect, used alone and in combination with other anticonvulsant drugs, it was stated that it was most effective in the treatment of temporal lobe attacks and other types of focal seizure, 5&90yu of patients with such attacks being markedly improved. It was less effective in the control of major seizures ( I , 3,6). There is a lack of sedative effect, but several side effects were observed, the most common being paraesthesiae in the extremities, usually disappearing despite continuation of treatment.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Sulthiame, a New Anticonvulsant Drug in the Treatment of Temporal Lobe Epilepsy

Fenton¹,

Serafetinides²,

Pond³

1964

Epilepsia

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SUMMARY A series of 25 in‐patients and out‐patients with predominantly temporal lobe epilepsy were treated with sulthiame alone or in combination with their previous anticonvulsant medication. About half showed improvement particularly those with fits in association with menstruation. Sulthiame is rarely effective alone. Side‐effects are common, especially dyspnoea and status epilepticus is a complication. Contra‐indications to the use of this drug are renal disease and a previous history of status. RÉSUMÉ Une série de 25 malades hospitalisés et ambulants atteints d'épilepsie du lobe temporal principalement ont été traités par du sulthiame seul ou en combinaison avec leur traitement anticonvulsif antérieur. La moitié d'entre eux à peu près et particulièrement les personnes dont les accès se produisaient en combinaison avec la menstruation, ont manifesté de l'amélioration. Le sulthiame employé seul est rarement efficace. Les symptômes secondaires sont fréquents, surtout dyspnée et état de mal sont une complication. Une affection rénale ou les symptômes préliminaires d'un état de mal sont des contraindications à l'emploi de ce médicament.

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An emission-controlled field desorption and electron impact spectrometry study of someN-substituted propane and butane sultams

Schulten

Nibbering

1977

Biol. Mass Spectrom.

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It is shown that the production of field desorption mass spectra with an emission-controlled emitter heating device is a useful tool in obtaining information about molecular structures. Since the structurally significant signals are sometimes missing in the corresponding electron impact spectra but not in the field desorption spectra the use of field desorption mass spectrometry appears to be more advantages. This will be especially true for substances that are thermally labile, unvolatile or unstable upon electron impact (both at high and low electron energy), the latter being the case for some of the compounds presently investigated which are derivatives of a drug with antitumour and antiepileptic effects. Further, emission-controlled desorption improves the reproducibility of the spectra obtained and thus appears to be a prerequisite for quantification in biomedical and pharmacokinetic studies.

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Zur Stellung des Butansultamderivates Ospolot in der Behandlung zerebraler Anfallsleiden

Cited by 26 publications

References 0 publications

Early human studies of a new carbonic anhydrase inhibitor (NSD 3004) with anticonvulsant properties

Early human studies of a new carbonic anhydrase inhibitor (NSD 3004) with anticonvulsant properties

The Effect of Sulthiame, a New Anticonvulsant Drug in the Treatment of Temporal Lobe Epilepsy

An emission-controlled field desorption and electron impact spectrometry study of someN-substituted propane and butane sultams

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