Early human studies of a new carbonic anhydrase inhibitor (NSD 3004) with anticonvulsant properties

Blood disposition and urinary excretion kinetics of methazolamide following oral administration to human subjects

“…Bayne reported measuring MTZ in RBCs 1082 h after administration at a concentration which represented approximately 6% of the administered dose [12]. Additionally, clinical studies with 2-amino-4-phenylsulphonylbenzenesulphonamide found measurable amounts of drug in RBCs for more than a year after drug administration [23]. Thus, the findings of our investigation are supported by data from previous investigators.…”

“…Consequently, a second, slower, elimination phase is established where RBC concentrations decline very slowly relative to plasma levels. Such behavior has been shown previously for MTZ [11] and 2-amino-4-phenylsulphonylbenzenesulphonamide [23].…”