“…8 This model accounts for the firstpass metabolism of VEN to O-desmethylvenlafaxine via CYP2D6 and consists of three transit compartments for absorption and one compartment for elimination (Figure S2). 8,17,18 In accordance with previously published similar models, we fixed the volume of distribution of O-desmethylvenlafaxine at 210 L, the hepatic plasma flow at University, St. Louis, Missouri, USA; 9 Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; 10 Clinical Laboratory and Diagnostic Services, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; 11 Division of Research in Patient Services, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. *Correspondence: Daniel J. Müller (daniel.mueller@camh.ca) † The first two authors contributed equally to the work; the last two ("senior") authors contributed equally to the work; except for the first three authors and the last three authors, all authors contributed equally and are listed in alphabetical order.…”