Abstract:In the course of studies on chemical carcinogenesis, which included animal experiments with a carcinogenic azo dye and a mathematical analysis of the observed effects, Hermann Druckrey and Karl Küpfmüller showed in 1948 that carcinogens induce heritable changes by targeting cellular "substances capable of self-reproduction". The authors did not discuss the chemical nature of these substances which remained unclear for a long time thereafter. It was not until 1964 that deoxyribonucleic acid (DNA) was recognized… Show more
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