Zur Reuter-Forschung

Sulfameter in Clinical Medicine

“…All sulfonamides are acetylated and conjugated with glucuronide in the N 4 or amine position. Ninety‐four per cent of sulfamethoxydiazine is free, as is 72–95 per cent of sulfamethoxypyridazine, 85 per cent of sulfadimethoxine, 94 per cent of sulfalene, and 94 per cent of R04‐4393 (10,22). Animal studies indicate that the toxicity of sulfamethoxydiazine is similar to that of sulfadimethoxine (22).…”