Zur Qualität und Quantität der therapeutischen Wirkung von Neuroleptika, trizyklischen Thymoleptika und Konvulsionsmethoden bei endogenen Depressionen

Abstract

Eight tricyclic thymoleptics, six neuroleptics and convulsion methods were compared as for therapeutical efficiency in 895 treatments of endogenous depression. Distribution in the scheme was performed according to the index of antidepressive effect (see diagram) representing the qualitative differences in applied therapeutical methods. In quantitative therapeutical efficiency, convulsive treatment demonstrated significantly more favourable results than drugs; tricyclic thymoleptics did not differ significantly from neuroleptic drugs. The tested piperazine phenothiazines achieved the therapeutic efficiency of levopromazine and thioridazine only by adding antiparkinsonian drugs.

Therapeutic Effect and Plasma Level of Thioridazine

“…There are also controlled studies comparing the antidepressant effect of thioridazine with that of tricyclic antidepressants, particularly imipramine (Overall et al (1964), Ndhunek (1969), Hanlow et al (1969), Luthe (1969)). The antidepressant effects of these drugs were comparable.…”