Correlation between the experimental data from animal studies and therapeutical effects of antidepressant drugs

Benešová, O; Náhunek, K

doi:10.1007/bf00403565

“…First, although cyclobenzaprine is structurally similar to amitriptyline (difference of one double bond), it is possibly less potent than other tricyclics [3]. In animal models, it also has some antiepileptic effects ,which is consistent with its possible antispastic effects [20].…”

Section: Discussionmentioning

confidence: 93%

Incidence of tricyclic antidepressant-like complications after cyclobenzaprine overdose

Bebarta

¹

,

Maddry

²

,

Borys

³

et al. 2012

The American Journal of Emergency Medicine

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Background: The cyclobenzaprine structure is similar to amitriptyline; however, tricyclic antidepressant (TCA)-like wide complex dysrhythmia has not been reported. Our objective was to determine the incidence of TCA-like effects in cyclobenzaprine overdoses as reported to 6 poison centers for 2 years. We compared the incidence of these effects to amitriptyline overdoses collected during the same period. Methods: We performed a retrospective review of 2 years of cases as reported to the Texas Poison Center Network. We identified sole ingestions of cyclobenzaprine and of amitriptyline. Cases had a recorded clinical outcome and clinical effect. A trained reviewer used a standard data collection sheet within a secured electronic database. One investigator audited a random sample of charts. Results: We identified 3974 cases of cyclobenzaprine calls. Of these, we collected 209 cases of acute overdoses without coingestions. There were no deaths. No cases of cyclobenzaprine ingestions were reported to have died or have a wide QRS or ventricular dysrhythmia. Seizures were reported in 2 cases; however, both were unrelated to cyclobenzaprine. Hypotension was reported in 1.4% (3/209) of cases, and a vasopressor was used in one case (0.5%). Patients with an amitriptyline overdose were more likely to have seizure, coma, tachycardia, a wide QRS or ventricular dysrhythmia, and have received sodium bicarbonate or be intubated. Conclusions: Cyclobenzaprine overdoses were not reported to cause widened QRS, ventricular dysrhythmias, or seizures, and hypotension was rarely reported. Tricyclic antidepressant-related effects occurred more often in our comparison group of amitriptyline overdoses.

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“…The value of this antimuscarinic property in combating depressive illness has been only partially unexplored (Blackwell et al, 1972), although in animal neuropharmacological tests this effect is not conspicuous (Spencer, 1965;1966). Benesova & Nahunek (1971) show that imipramine and its close analogues are able to potentiate the central (and peripheral) effects of NA and/or 5-HT, that this is their overwhelming pharmacological property, and seems to correlate with our current knowledge of the biochemical basis of depressive illness. The tricyclics do not stimulate NA and 5-HT receptors, nor do they release endogenous amines; at high doses they may even exert a postsynaptic receptor-blocking action, reminiscent of the neuroleptics.…”

Section: Imipramine and Related Tricyclic Membrane-pump Inhibitorsmentioning

confidence: 89%

“…The value of this antimuscarinic property in combating depressive illness has been only partially unexplored (Blackwell et al, 1972), although in animal neuropharmacological tests this effect is not conspicuous (Spencer, 1965;1966). Benesova & Nahunek (1971) (Mallion et al, 1972) and (Greenwood, 1975). Brief reports of its clinical pharmacological activity have been given by Kirby & Turner (1974), Bayliss & Duncan (1974) and Turner et al (1975).…”

Section: Imipramine and Related Tricyclic Membrane-pump Inhibitorsmentioning

confidence: 99%

Review of the pharmacology of existing antidepressants.

Spencer¹

1977

Brit J Clinical Pharma

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“…It is a weak inhibitor of norepinephrine and serotonin reuptake. It was created as antidepressant but had more adverse effects and less antidepressant effects than other tricyclic antidepressants (TCAs) [2,3]. It is the most common prescribed muscle relaxant and accounts for 18% of all prescriptions written for chronic back pain [4].…”

Section: Introductionmentioning

confidence: 99%

Incidence of tricyclic antidepressant-like complications after cyclobenzaprine overdose

Bebarta

¹

,

Maddry

²

,

Borys

³

et al. 2011

The American Journal of Emergency Medicine

View full text Add to dashboard Cite

Background: The cyclobenzaprine structure is similar to amitriptyline; however, tricyclic antidepressant (TCA)-like wide complex dysrhythmia has not been reported. Our objective was to determine the incidence of TCA-like effects in cyclobenzaprine overdoses as reported to 6 poison centers for 2 years. We compared the incidence of these effects to amitriptyline overdoses collected during the same period. Methods: We performed a retrospective review of 2 years of cases as reported to the Texas Poison Center Network. We identified sole ingestions of cyclobenzaprine and of amitriptyline. Cases had a recorded clinical outcome and clinical effect. A trained reviewer used a standard data collection sheet within a secured electronic database. One investigator audited a random sample of charts. Results: We identified 3974 cases of cyclobenzaprine calls. Of these, we collected 209 cases of acute overdoses without coingestions. There were no deaths. No cases of cyclobenzaprine ingestions were reported to have died or have a wide QRS or ventricular dysrhythmia. Seizures were reported in 2 cases; however, both were unrelated to cyclobenzaprine. Hypotension was reported in 1.4% (3/209) of cases, and a vasopressor was used in one case (0.5%). Patients with an amitriptyline overdose were more likely to have seizure, coma, tachycardia, a wide QRS or ventricular dysrhythmia, and have received sodium bicarbonate or be intubated. Conclusions: Cyclobenzaprine overdoses were not reported to cause widened QRS, ventricular dysrhythmias, or seizures, and hypotension was rarely reported. Tricyclic antidepressant-related effects occurred more often in our comparison group of amitriptyline overdoses.

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Correlation between the experimental data from animal studies and therapeutical effects of antidepressant drugs

Cited by 37 publications

References 17 publications

Incidence of tricyclic antidepressant-like complications after cyclobenzaprine overdose

Incidence of tricyclic antidepressant-like complications after cyclobenzaprine overdose

Review of the pharmacology of existing antidepressants.

Incidence of tricyclic antidepressant-like complications after cyclobenzaprine overdose

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