Review of the pharmacology of existing antidepressants.

Spencer, P.S.

doi:10.1111/j.1365-2125.1977.tb05761.x

Cited by 33 publications

(11 citation statements)

References 52 publications

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“…A dramatic effect was seen when three recently developed antidepressant drugs were studied (Spencer, 1977). Mianserin and viloxazine appeared to be completely without effect on hamster spermatozoa, but nomifensine significantly decreased sperm motility and whiplash motility in epididymal sperm suspensions and in the egg-containing droplets.…”

Section: Discussionmentioning

confidence: 96%

Effect of antidepressant drugs on the in-vitro eggpenetrating ability of golden hamster epididymal spermatozoa

Stein¹,

Schnieden²

1983

Reproduction

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Tricyclic antidepressants appeared to be without effect, except for desipramine which significantly decreased whiplash motility after spermatozoa were added to eggs, and clomipramine which decreased motility and whiplash motility in epididymal sperm suspensions after pretreatment of males. Mianserin and viloxazine were also without effect, but nomifensine significantly decreased sperm motility and whiplash motility and inhibited egg penetration almost completely. After 3 h preincubation with 0\m=.\75mmol nomifensine hydrogen maleate/l, 2/181 and 0/256 eggs were penetrated in two separate series of experiments. Control groups in these series gave medians of 90\p=n-\100%penetration by 4\m=.\5\p=n-\5\m=.\5h after spermatozoa and eggs were mixed. Maleic acid had a similar effect (1/253 eggs penetrated) whilst nomifensine hydrochloride was inactive, suggesting that the effect was due to the maleate moiety of the original nomifensine hydrogen maleate salt used.

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Section: Discussionmentioning

confidence: 96%

Effect of antidepressant drugs on the in-vitro eggpenetrating ability of golden hamster epididymal spermatozoa

Stein¹,

Schnieden²

1983

Reproduction

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“…Treatment is often associated with varying degrees of anticholinergic side-effects and sedation (Spencer, 1977). This present study employed amitriptyline as a positive control in this respect.…”

Section: Discussionmentioning

confidence: 99%

A comparison of the pharmacodynamic profiles of nomifensine and amitriptyline in normal subjects.

Chan¹,

Ehsanullah²,

Wadsworth³

et al. 1980

Brit J Clinical Pharma

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1 Six healthy male volunteers participated in a double-blind placebo crossover comparison of the pharmacodynamic profiles of single oral doses of 75 mg nomifensine and 50 mg amitriptyline. 2 Nomifensine treatment did not influence salivary flow and did not significantly affect psychomotor performance (critical flicker fusion, pursuit rotor and reaction time): in addition nomifensine had no significant effect on subjective measurements of sedation and concentration. 3 By contrast, amitriptyline treatment significantly reduced salivary flow and was associated with significant sedation and reduced concentration: significant changes in psychomotor performance were also noted. 4 Plasma concentrations of amitriptyline and nomifensine were measured at 2 h. The respective median concentration values were 55.0 ng/ml and 52.0 ng/ml. 5Ex vivo platelet amine uptake of dopamine (DA) and 5-hydroxytryptamine (5HT) was measured 2 h after each treatment. Both nomifensine and amitriptyline treatment significantly inhibited DA uptake to a similar extent. Amitriptyline treatment additionally inhibited 5-HT uptake.

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“…Brain a.mines have many roles in relation to mammalian behaviour (Baldessarini 1972). In turn, the vast majority of psychotropic drugs can be shown to affect in the brain, one or more of the following transmitters: NA, TIA, 5HT and .AC h ( Spencer 1977) • -32 -The impulse to study brain amines in relation to depressive illness was provided by pharmacological observations made in the 1950's with the widespread use of reserpine in psychiatry and hypertension. Reserpine (rauwolfia) induced depression in 7% to 26% of patients (Muller et al 1955;Harris 1957;Faucett 1958) and it was possible that this effect of reserpine was due to a substantial depletion of brain amines.…”

Section: The Monoamine and Neurotransmitter Hypothesesmentioning

confidence: 99%

“…The biochemical changes are therefore unlikely to be qualititatively different (Ridges 1975); instead they are likely to be quantitative changes, perhaps highly localised within the brain, reflecting merely exaggerated intensity or duration of a depressive reaction which is typical of the clinical condition (Spencer 1977). Brain a.mines have many roles in relation to mammalian behaviour (Baldessarini 1972).…”

Section: The Monoamine and Neurotransmitter Hypothesesmentioning

confidence: 99%

Depression in Patients With Epilepsy

Robertson¹

1984

Clinical Neuropharmacology

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Review of the pharmacology of existing antidepressants.

Cited by 33 publications

References 52 publications

Effect of antidepressant drugs on the in-vitro eggpenetrating ability of golden hamster epididymal spermatozoa

Effect of antidepressant drugs on the in-vitro eggpenetrating ability of golden hamster epididymal spermatozoa

A comparison of the pharmacodynamic profiles of nomifensine and amitriptyline in normal subjects.

Depression in Patients With Epilepsy

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