Zur Pathogenese der Magenkrebse und über ihren gelegentlichen Ursprung aus angeborenen epithelialen Keimen in der Magenwand<sup>1</sup>)

Askanazy, M.

doi:10.1055/s-0028-1131758

Cited by 14 publications

(9 citation statements)

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“…The concentration in the primary tumour was in general lower than in the lymph node and liver metastases, but the concentration was 10 times higher than in the surrounding stomach wall. Northern blot analysis of liver metastases demonstrated mRNA for all five subtypes of the somatostatin receptor (sst [1][2][3][4][5] ). The transcript sizes were of expected size: sstr 1 4.3 kb, sstr 2 2.4 and 8.9 kb, sstr 3 4.9 kb, sstr 4 about 4.7 kb, and sstr 5 4.0 kb (fig.…”

Section: Somatostatin Receptors In Gastric Carcinoidmentioning

confidence: 99%

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Gastric Carcinoid with Histamine Production, Histamine Transporter and Expression of Somatostatin Receptors

Kölby¹,

Wängberg²,

Ahlman³

et al. 1998

Digestion

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A case of sporadic, histamine-producing gastric carcinoid with liver metastases is reported. The patient was treated with somatostatin analogue (octreotide) combined with cortisone and blockade of histamine receptors prior to surgery, which included subtotal gastrectomy, excision of lymph node metastases and superficial liver metastases. Residual liver metastases were injected with ethanol. These interventions markedly reduced the urinary excretion of the main histamine metabolite (MeImAA). Eighteen months later combined immuno- and chemotherapy was initiated due to tumour progression and recurrent hormonal symptoms with good clinical results over 12 months. Scintigraphy, using ¹¹¹In-DTPA-D-Phe¹-octreotide, visualized somatostatin receptors (sstr) in primary tumour, lymph node metastases and liver metastases. The tissue/blood ¹¹¹In concentration ratios of tumour biopsies were very high. Northern analyses confirmed expression of all subtypes of sstr_1–5. Immunocytochemically, tumour cells were strongly positive for chromogranin A, histamine and vesicular monoamine transporter (VMAT) 2 (histamine transporter), but negative for VMAT 1, suggesting an origin from gastric enterochromaffin-like cells. In primary tumour cell cultures, histamine, 5-HTP and 5-HIAA, but not 5-HT, could be detected in conditioned culture medium, indicating a defective decarboxylation of the tryptamine precursor. This rare case of histamine-producing gastric carcinoid demonstrates that excellent symptom relief can be achieved despite disseminated disease, if active, multimodal treatment strategy is instituted. The presence of high numbers of sstr in tumour tissue also raises the possibility of receptor-guided radiotherapy.

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Section: Somatostatin Receptors In Gastric Carcinoidmentioning

confidence: 99%

“…The first report on a gastric carcinoid was made by Askanazy [1] in 1923. In the pre-endoscopic era, gastric carcinoids constituted 0.3% of all gastric tumours and 3% of all gastrointestinal carcinoids [2].…”

Section: Introductionmentioning

confidence: 99%

Gastric Carcinoid with Histamine Production, Histamine Transporter and Expression of Somatostatin Receptors

Kölby¹,

Wängberg²,

Ahlman³

et al. 1998

Digestion

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“…One large review documented failure of complete reversal of symptoms with vitamin B 12 replacement, yet showed improvement in frontal lobe function and language abilities. 4 Gastric carcinoids, first described by Askanazy in 1923, 5 represent an equally uncommon oncologic manifestation of both the gastric and enterochromaffin-like (ECL) tissues. Less than 1% of all carcinoid tumors present in the gastric mucosa, and less than 2% of gastric neoplasms are carcinoid in origin.…”

Section: Discussionmentioning

confidence: 99%

79-Year-Old Woman With Forgetfulness

Palmer

Crozier

Petrucelli

2012

Mayo Clinic Proceedings

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“…Ein Karzinoid des Magens wurde erstmals von Askanazy [4] 1923 beschrieben. Durch Untersuchungen mehrerer Arbeitsgruppen [8,11,30] in den letzten Jahren haben sich verschiedene Charakteristika herausarbeiten lassen, die die Unterteilung der Magenkarzinoide in 4 Gruppen erlauben (Tabelle 1).…”

Section: Klassifikation Der Magenkarzinoideunclassified

Therapie der Karzinoide des Magens

Becker

Gabriel

1996

Langenbecks Arch Chir

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Carcinoids of the stomach are rare but have gained importance since the introduction of acid secretion inhibitors. The most important type is the tumor occurring in patients with chronic atrophic gastritis with and without pernicious anemia. The tumors are benign and can be treated by local endoscopic or surgical methods. Antrectomy reduces hypergastrinemia and may cause regression of the tumor. Sporadic carcinoids of the gastric antrum are malignant, however, and require radical surgical treatment.

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Zur Pathogenese der Magenkrebse und über ihren gelegentlichen Ursprung aus angeborenen epithelialen Keimen in der Magenwand¹)

Cited by 14 publications

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Gastric Carcinoid with Histamine Production, Histamine Transporter and Expression of Somatostatin Receptors

Gastric Carcinoid with Histamine Production, Histamine Transporter and Expression of Somatostatin Receptors

79-Year-Old Woman With Forgetfulness

Therapie der Karzinoide des Magens

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Zur Pathogenese der Magenkrebse und über ihren gelegentlichen Ursprung aus angeborenen epithelialen Keimen in der Magenwand1)

Cited by 14 publications

References 0 publications

Gastric Carcinoid with Histamine Production, Histamine Transporter and Expression of Somatostatin Receptors

Gastric Carcinoid with Histamine Production, Histamine Transporter and Expression of Somatostatin Receptors

79-Year-Old Woman With Forgetfulness

Therapie der Karzinoide des Magens

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Zur Pathogenese der Magenkrebse und über ihren gelegentlichen Ursprung aus angeborenen epithelialen Keimen in der Magenwand¹)