Zur Pathogenese der Magenkrebse und über ihren gelegentlichen Ursprung aus angeborenen epithelialen Keimen in der Magenwand (Schluß aus Nr. 1.)

Askanazy, M.

doi:10.1055/s-0028-1131778

Cited by 43 publications

(8 citation statements)

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“…Even today, 70 years after the first report on carcinoid tumours of the stomach by von Askanazy [1], the progno sis of these tumours is not yet clear, and we still have no definitive therapeutic concept for the treatment of gastric carcinoid tumours.…”

Section: Introductionmentioning

confidence: 99%

Prognosis of Gastric Carcinoid Tumours

Rappel¹,

Altendorf-Hofmann

Stolte³

1995

Digestion

124

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With the aim of evaluating the prognosis of carcinoid tumours of the stomach, the tumours were classified into subtypes on the basis of the type of gastritis, and a comparison made of the type of treatment, metastasizing rate, and the survival rates of the various groups of patients involved. Of the patients with atrophic autoimmune gastritis (type A gastritis) (n = 88) who had multiple carcinoid tumours in the corpus or fundus, usually not more than 1 cm in diameter, 98% were followed up clinically or by endoscopy and biopsy. In these patients, the metastasizing rate was 0%, and the age-corrected Kaplan-Meier survival rate revealed normal life expectancy. 25% of the patients with sporadic carcinoid tumours (n = 12) – most of whom had a Helicobacter pylori-related gastritis and usually solitary tumours located within the corpus or fundus, 25% of which exceeding 1 cm in diameter – underwent surgical treatment. In these patients the metastasizing rate was 16.7% and the age-corrected survival rate 79%. On the basis of our results, we conclude that, depending upon the subtype involved, the prognosis of gastric carcinoid tumours varies, such that regular endoscopy/biopsy follow-up suffices for patients with type A gastritis, while for patients with sporadic carcinoid tumours, surgical treatment is indicated.

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Section: Introductionmentioning

confidence: 99%

Prognosis of Gastric Carcinoid Tumours

Rappel¹,

Altendorf-Hofmann

Stolte³

1995

Digestion

124

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“…Obendorfer y Frankfurt acuñaron el término carcinoide en 1907 para separar un grupo de tumores del intestino delgado que se comportaban menos agresivos que los carcinomas convencionales 4 . Tumores carcinoides gástricos, fueron reportados por primera vez por Askanazy en 1923 5 . Actualmente, la Organización Mundial de la Salud, clasifica estos tumores como neuroendocrinos 6 , siendo el término carcinoide aplicado para tumores neuroendocrinos bien diferenciados originados en el tracto gastrointestinal, broncopulmonar u otros sitios infrecuentes.…”

Section: Discussionunclassified

Tumor neuroendocrino Tipo 1: reporte de un caso y revisión de la literatura

et al. 2020

Rev. Cirugia

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Introducción: Los tumores neuroendocrinos (TNE), son tumores compuestos por células productoras de péptidos y aminas. Los TNE gástricos, representan el 1% de todas las neoplasias, sin embargo su incidencia ha ido en aumento. Son generalmente asintomáticos y no funcionantes. El tratamiento es generalmente la resección local.Caso Clínico: paciente de 48 años con sospecha de cáncer gástrico; su estudio demuestra un TNE gástrico bien diferenciado tipo 1. Se realiza etapificación y se define en comité oncológico la vigilancia endoscópica. El hallazgo de un TNE, en el estudio de cáncer gástrico, es un hallazgo poco frecuente. Debido al aumento progresivo en la realización de endoscopías digestivas altas, secundario a la alta prevalencia de cáncer gástrico en nuestro país, se espera que aumenten hallazgos como un TNE. Es por esto que realizamos una revisión de la literatura y planteamos algunas conclusiones al respecto.

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“…Der Begriff "Karzinoid" wurde zuerst 1907 von Oberndorfer eingeführt, um Tumore zu beschreiben, die sich weniger aggressiv zu verhalten schienen als Adenokarzinome [17]. Die erste Beschreibung eines "Karzinoid des Magens" stammt aus dem Jahre 1923 von dem Genfer Pathologen Askanazy, der zur Pathogenese der Magenkarzinoide in der Deutschen Medizinischen Wochenschrift eine Abhandlung veröffent-lichte [2].Ursprünglich wurden diese Neubildungen wie alle anderen neuroendokrinen Tumore unter dem Sammelbegriff Karzinoide zusammengefasst, der zunächst nur den Serotonin produzierenden semimalignen Tumor bezeichnete. Nachdem immunhistochemisch eine Reihe verschiedener neuroendokriner Hormone in Karzinoidzellen nachgewiesen werden konnte,wurde 1980 der alte Begriff "Karzinoid" durch den des "neuroendokrinen Tumors (NET)" ersetzt [8,25].Dieser umfasst alle Neoplasien des diffusen neuroendokrinen Zellsystems mit Ausnahme der endokrinen Tumoren des Pankreas, der medullären Schilddrüsenkarzinome,der Paragangliome,der kleinzelligen Lungenkarzinome und der Merkel-Zell-Tumoren der Haut [1,10,13].…”

Section: Schlüsselwörterunclassified

Neuroendokrine Tumore des Magens Chirurgische Therapie und Prognose

Bektaş¹,

Piso²,

Werner³

et al. 2002

Chirurg

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Gastric carcinoid tumors are rare lesions characterized by hypergastrinemia that arise from enterochromaffin-like (ECL) cells of the stomach. A classification system distinguishing three types of gastric carcinoid tumors has been proposed: 1) tumors related to chronic atrophic gastritis, 2) tumors associated with Zollinger-Ellison syndrome, and 3) sporadic lesions. It is apparent that hypergastrinemia-associated gastric carcinoids show a rather benign biological behavior. Normo-gastrinemic sporadic lesions, on the other hand, require an aggressive surgical management. We report seven patients with gastric neuroendocrine tumors ("carcinoids"), who underwent surgical treatment in our department between 1988 and 2000. Surgical therapy included total gastrectomy with D2 lymphadenectomy in two cases with type I tumors and for one patient with type III tumor. One patient with a type II tumor was treated by distal subtotal gastrectomy and another by antrectomy. A local excision was performed on one patient with type I tumor. After a mean follow-up of 8 years, 5 of 7 patients are alive without recurrence.

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Zur Pathogenese der Magenkrebse und über ihren gelegentlichen Ursprung aus angeborenen epithelialen Keimen in der Magenwand (Schluß aus Nr. 1.)

Cited by 43 publications

References 0 publications

Prognosis of Gastric Carcinoid Tumours

Prognosis of Gastric Carcinoid Tumours

Tumor neuroendocrino Tipo 1: reporte de un caso y revisión de la literatura

Neuroendokrine Tumore des Magens Chirurgische Therapie und Prognose

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