Zur Oxydation von Polyethylenoxiden und Polyethylenoxidethern; Die Bildung von Acetaldehyd bei der Oxydation von Diethylenglycol mit Sauerstoff

Gerhardt, Werner; Martens, Christiane

doi:10.1002/zfch.19850250412

Cited by 20 publications

(9 citation statements)

References 7 publications

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“…Unwanted side effects [157] as severe hyper sensitivity [158] or anaphylactic reactions [159] and non long-term biocompatibility of PEG coatings are still problematic. Furthermore, PEG rapidly auto oxidizes ex vivo (particularly in the presence of oxygen and transition metal ions) [160][161][162] and the termal hydroxyl group of PEG can also be oxidized enzymatically to aldehydes and acids in vivo, allowing proteins and cells to attach [163,164].…”

Section: Pegmentioning

confidence: 99%

Coating Matters: Review on Colloidal Stability of Nanoparticles with Biocompatible Coatings in Biological Media, Living Cells and Organisms

Schubert

Chanana

2018

CMC

114

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Within the last two decades, the field of nanomedicine has not developed as successfully as has widely been hoped for. The main reason for this is the immense complexity of the biological systems, including the physico-chemical properties of the biological fluids as well as the biochemistry and the physiology of living systems. The nanoparticles' physico-chemical properties are also highly important. These differ profoundly from those of freshly synthesized particles when applied in biological/living systems as recent research in this field reveals. The physico-chemical properties of nanoparticles are predefined by their structural and functional design (core and coating material) and are highly affected by their interaction with the environment (temperature, pH, salt, proteins, cells). Since the coating material is the first part of the particle to come in contact with the environment, it does not only provide biocompatibility, but also defines the behavior (e.g. colloidal stability) and the fate (degradation, excretion, accumulation) of nanoparticles in the living systems. Hence, the coating matters, when designing a nanoparticle system for biomedical applications, which has to fulfill its task in the complex environment of biological fluids, cells and organisms. In this review, we evaluate the performance of different coating materials for nanoparticles concerning their ability to provide colloidal stability in biological media and living systems.

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Section: Pegmentioning

confidence: 99%

Coating Matters: Review on Colloidal Stability of Nanoparticles with Biocompatible Coatings in Biological Media, Living Cells and Organisms

Schubert

Chanana

2018

CMC

114

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“…Modification of PDMS with polyethyleneglycol (PEG) has been found to be a convenient way to increase hydrophilicity, while maintaining the electrically neutral character and biocompatibility of the material . However, relatively poor chemical stability of PEG in the presence of oxygen and transition metal ions, or through enzymatic processes, has incited further interest into more stable, nonfouling and biocompatible materials . In recent years the modification of hydrophobic PDMS using zwitterionic polymers has emerged as a promising method, which increases hydrophilicity of the material and imparts fouling resistant properties .…”

Section: Introductionmentioning

confidence: 99%

Improved Antifouling Properties of Polydimethylsiloxane Films via Formation of Polysiloxane/Polyzwitterion Interpenetrating Networks

Dundua

Franzka

Ulbricht

2016

Macromol. Rapid Commun.

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Nonspecific adsorption of proteins is a challenging problem for the development of biocompatible materials, as well as for antifouling and fouling-release coatings, for instance for the marine industry. The concept of preparing amphiphilic systems based on low surface energy hydrophobic materials via their hydrophilic modification is being widely pursued. This work describes a novel two-step route for the preparation of interpenetrating polymer networks of otherwise incompatible poly(dimethylsiloxane) and zwitterionic polymers. Changes in surface hydrophilicity as well as surface charge at different pH values are investigated. Characterization using atomic force microscopy provides thorough insight into surface changes upon hydrophilic modification. Protein fouling of the materials is assessed using fibrinogen as a model protein.

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“…All three coatings significantly reduced nonspecific protein adsorption (bovine serum albumin) and bacterial ( S. sanguinis and Lactobacillus salivarius ) adhesion. The tendency of PEG to be oxidized under sterilization conditions or in vivo , in the presence of oxygen and transition metal ions, , however, could lead to its eventual fouling and compromise its long-term antifouling performances.…”

Section: Antifouling Implant Surface Modificationsmentioning

confidence: 99%

Anti-Periprosthetic Infection Strategies: From Implant Surface Topographical Engineering to Smart Drug-Releasing Coatings

Ghimire

Song

2021

ACS Appl. Mater. Interfaces

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Despite advanced implant sterilization and aseptic surgical techniques, periprosthetic bacterial infection remains a major challenge for orthopedic and dental implants. Bacterial colonization/biofilm formation around implants and their invasion into the dense skeletal tissue matrices are difficult to treat and could lead to implant failure and osteomyelitis. These complications require major revision surgeries and extended antibiotic therapies that are associated with high treatment cost, morbidity, and even mortality. Effective preventative measures mitigating risks for implant-related infections are thus in dire need. This review focuses on recent developments of anti-periprosthetic infection strategies aimed at either reducing bacterial adhesion, colonization, and biofilm formation or killing bacteria directly in contact with and/or in the vicinity of implants. These goals are accomplished through antifouling, quorum-sensing interfering, or bactericidal implant surface topographical engineering or surface coatings through chemical modifications. Surface topographical engineering of lotus leaf mimicking super-hydrophobic antifouling features and cicada wing-mimicking, bacterium-piercing nanopillars are both presented. Conventional physical coating/passive release of bactericidal agents is contrasted with their covalent tethering to implant surfaces through either stable linkages or linkages labile to bacterial enzyme cleavage or environmental perturbations. Pros and cons of these emerging anti-periprosthetic infection approaches are discussed in terms of their safety, efficacy, and translational potentials.

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Zur Oxydation von Polyethylenoxiden und Polyethylenoxidethern; Die Bildung von Acetaldehyd bei der Oxydation von Diethylenglycol mit Sauerstoff

Cited by 20 publications

References 7 publications

Coating Matters: Review on Colloidal Stability of Nanoparticles with Biocompatible Coatings in Biological Media, Living Cells and Organisms

Coating Matters: Review on Colloidal Stability of Nanoparticles with Biocompatible Coatings in Biological Media, Living Cells and Organisms

Improved Antifouling Properties of Polydimethylsiloxane Films via Formation of Polysiloxane/Polyzwitterion Interpenetrating Networks

Anti-Periprosthetic Infection Strategies: From Implant Surface Topographical Engineering to Smart Drug-Releasing Coatings

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