Zur Morphinbestimmung in Kopfhaaren

Klug, E

doi:10.1007/bf01866570

Cited by 40 publications

(10 citation statements)

References 5 publications

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“…2. The detection of the drugs after successive hair washing indicates that the substances were contained within the hair and not on the surface (Goldblum et al 1954;Harrison et al 1974;Klug 1980;Baumgartner et al 1981;Valente et al 1981;Baumgartner et al 1982;Niwaguchi et al 1983;Puschel et al 1983;Suzuki et al 1984).…”

Section: Discussionmentioning

confidence: 96%

Radioimmunological determination of cocaine in human hair

1987

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Summary.A simple procedure for the determination of cocaine in human hair was described. After washing hair samples were crushed in 0.1 m HC1 and incubated overnight at 45°C. The acid extracts were neutralized with 1 m NaOH. Phosphate buffer (pH 7.4) was added to the extracts. The cocaine concentrations were measured by radioimmunoassay. Detection in hair was achieved in all hair samples obtained from cocaine users. This method appears to be suitable for the routine determination of cocaine. Key word: Cocaine, radioimmunological determination in hairZusammenfassung. Diese Arbeit beschreibt eine Methode fiir die Bestimmung von Kokain im menschlichen Haar. Das Haar wurde gewaschen, zermalt mit 0,1m HC1 und tiber Nacht bei 45°C inkubiert. Nach Neutralisierung mit 1 m NaOH wurde Phosphat-Puffer (pH 7,4) zugesetzt. Die KokainKonzentrationen wurden mittels Radioimmunoassay bestimmt. In allen Haarproben yon Kokainabh~ingigen wurden megbare Konzentrationen nachgewiesen. Dieses Veffahren stellt eine schnelle und einfache Routinemethode dar.

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Section: Discussionmentioning

confidence: 96%

Radioimmunological determination of cocaine in human hair

1987

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“…Nearly ten years later Baumgartner et al (5) in the USA and in Europe Klug (16) and Arnold, Püschel et al (2,3,4,(17)(18)(19) first discovered opiates in human hair of the head by means of radioimmunological methods. In the course of further examination -carried out with radioimmunoassays (RIA) -phencyclidine (20), methaqualone (21), cocaine (22) and amphetamine (23) were identified and the results were partly verifled by mass spectrometry and gas chromatography.…”

Section: Hair Analysis For Organic Pharmaceuticalsmentioning

confidence: 99%

Radioimmunological Hair Analysis for Narcotics and Substitutes

Arnold

1987

Clinical Chemistry and Laboratory Medicine

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Summary:In recent years it has become possible to detect organic pharmaceuticals and poisons in a few milligrams of hair, using radioimmunological methods. Some methods are specific for individual compounds, others for groups of compounds. This is of great irnportance inter alia for forensic purposes, especially in cases of dmg abuse. With the help of such hair analysis it is possible to trace the drug career of an addicted person for up to one year, and in certain cases for a longer period. Frequently, the results provide Information on events in the rather distant past. This can be of considerable anamnestic and forensic importance.

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“…Baumgartner et al [16], Klug [17] and Nagai et al [7] reported that hair is one of the sties of in vivo deposition of narcotics and stimulants, and that their accumulation is associated with the history of abuse. The transfer of MAMP and AMP into the hair is not known minutely.…”

Section: Discussionmentioning

confidence: 99%

Forensic toxicologic analysis of methamphetamine and amphetamine optical isomers by high performance liquid chromatography

Nagai

Kamiyama

1988

Z Rechtsmed

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Optical isomers (d and l) and racemic compounds (dl) of methamphetamine (MAMP) and amphetamine (AMP), and biologic materials including those substances, could be analyzed by high performance liquid chromatography. Examining the temperature for the analysis, 40 degrees C was the optimal condition in the reproducibility of separated MAMP-isomers. The reproducibility at the temperature did not vary significantly. The measured values of optical isomers were 0.116 +/- 0.012, 1.082 +/- 0.070 and 8.984 +/- 0.136 for the mixing ratios (l/d) of 0.111, 1.000, and 9.000, respectively. The detection limit for both d- and l-isomers was 25 ng. The analytic result of hair specimens from two stimulant abusers by the present method indicates that they contained only d-MAMP and d-AMP, which is believed to have the strongest pharmacologic effect among the optical isomers of MAMP. The coefficient of variation in the analysis of five replicate standards, prepared by adding 1,000 ng each of racemate MAMP and AMP to hair, was less than 4%. The measured value against l/d = 1.000 was 1.040 +/- 0.040 in MAMP and 0.980 +/- 0.030 in AMP. The detection limit for both racemate MAMP and AMP accumulated in hair was 250 ng. The analysis of the optical isomers by our method would contribute to identifying the smuggling routes or the illicit method.

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Zur Morphinbestimmung in Kopfhaaren

Cited by 40 publications

References 5 publications

Radioimmunological determination of cocaine in human hair

Radioimmunological determination of cocaine in human hair

Radioimmunological Hair Analysis for Narcotics and Substitutes

Forensic toxicologic analysis of methamphetamine and amphetamine optical isomers by high performance liquid chromatography

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