Zur Kenntniss der Amidine und der Thiamide einbasischer organischer Säuren

Auto‐Tandem Catalysis: Synthesis of Acridines by Pd‐Catalyzed C=C Bond Formation and C(sp2)–N Cross‐Coupling

“…However, previous synthetic routes to obtain the acridine scaffold always involve multi‐step reaction sequences or harsh conditions 7. The Bernthsen reaction, a classic one‐pot approach towards acridines, requires a high temperature and an excess amount of Lewis acid, which drastically narrows the substrate scope (Scheme , a) 7a,7b. In 2010, Buchwald and co‐worker reported an acridine synthesis by an intramolecular Heck reaction (Scheme , b) 7c.…”

Synthesis of Acridines from o-Aminoaryl Ketones and Arylboronic Acids by Copper Trifluoroacetate-Mediated Relay Reactions

“…9-Methylacridines and other acridine-containing analogues have also been used in the construction of new fluorescent probes and as triplet-state, light-emitting materials for organic light-emitting diodes . A great amount of research has therefore focused on the construction of acridine cores and preparation of acridine-containing compounds. − The Brenthsen reaction, a classical approach to acridine synthesis, needs high temperatures and strongly acidic conditions to achieve electrophilic annulation of carboxylic acids with diarylamines, and this greatly narrows the substrate scope . Some effective methods that use noble-metal catalysts have been developed .…”

Synthesis of Substituted Acridines through a Palladium‐Catalyzed Condensation/Cyclization/Tautomerization Sequence

“…Consequently, interest in developing an efficient approach to produce various substituted acridine derivatives has been increasing . The classic Brenthsen reaction, which uses diphenylamines and carboxylic acids as starting materials in the presence of an excess amount of a Lewis acid at 200–270 °C, is the earliest practical synthetic method . In recent years, numerous novel synthetic routes to generate substituted acridines under relatively mild reaction conditions were successfully developed.…”