Zur Kenntnis des intermediären Stoffwechsels des Histidins Trennung von Histidase und Urocaninase. 6. Mitteilung

Edlbacher, S.; Viollier, G

doi:10.1515/bchm2.1942.276.3.108

Cited by 10 publications

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“…Histidine .-Several papers concerning the role of urocanic acid in histidine metabolism have only recently become available (143,144,145). As in most earlier studies, no urocanic acid was excreted after histidine was fed to dogs or injected in large doses into rabbits (143) or guinea pigs (145).…”

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The Metabolism of Proteins and Amino Acids

Berg¹

1944

Annu. Rev. Biochem.

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In the compilation of this review an attempt has been made to give appropriate recognition· to the current interest in normal and emer gency nutrition, by discussing such aspects as the amino acid needs of the human subject, the synthesis of blood proteins, intravenous ali mentation, and the use of urea by ruminants. References to papers in the fields of plant and bacterial metabolism have been largely omitted. During the year many delayed foreign journals have become available, but their arrival has been erratic and it has not been possible to fill some of the gaps. Throughout the review 1 and d have been used in the configurational sense.Essential amino acids.-The amino acid requirements for main tenance in the adult human subject have recently been tested with protein hydrolyzates and with mixtures of purified amino acids as the chief or sole source of protein nitrogen. Studies of the former type have come chiefly from the laboratory of Holt. Nitrogen equilibrium was readily maintained on an enzymic hydrolyzate of casein, but this was not possible with acid-hydrolyzed casein until tryptophan . �had been added (1, 2). Two other acid hydrolyzates were prepared, one from casein which had been deaminized to destroy the lysine (3) and the other from casein which had been oxidized with hydrogen perox ide (4, 5) to convert the methionine to the corresponding biologically inactive sulfone (6) which was removed as the insoluble calcium sul fonate. From the latter preparation most of the residual cystine was also removed by adsorption on norit. When the former hydrolyzate was fed in diets fortified with tryptophane, equilibrium was not at tained until lysine was added (7, 8). Supplementation of the latter hydrolyzate with tryptophane, methionine, and cystine provided a mix ture adequate for maintenance. Removal of the methionine produced negative nitrogen balances and loss of body weight; its restoration re-established nitrogen equilibrium in a few days, but did not increase the body weight. 0 The inconsistent results obtained by the omission of cystine were considered to suggest that cystine was essential, but this conclusion was t.bought to require confirmation (9). An abstract 239 Annu. Rev. Biochem. 1944.13:239-262. Downloaded from www.annualreviews.org Access provided by Technische Universiteit Eindhoven on 02/02/15. For personal use only.Quick links to online content Further ANNUAL REVIEWS

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The Metabolism of Proteins and Amino Acids

Berg¹

1944

Annu. Rev. Biochem.

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Die Beeinflussung des Histidinstoffwechsels durch Vitaminmangel und verschiedene Ernährungsweise

Edlbacher

Viollier

1943

Helvetica Chimica Acta

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Es wird die Erscheinung des erhöhten enzymatischen Histidin‐Abbaus im B1‐avitaminotischen Organismus weiter untersucht. Dabei ergibt sich: Parallel zum Verhalten der Histidase und der Arginase findet bei B1‐Avitaminose auch eine Erhöhung der Urocaninasespaltung statt. Entsprechend dem erhöhten Histidasespiegel der Leber ist die Histidin‐Ausscheidungsquote nach Belastung bei B1‐Mangel erniedrigt. B2‐ und B6‐avitaminotische Ratten zeigen nach Belastung das gleiche Verhalten wie Beri‐Beri‐Ratten. Die beobachtete Erhöhung des Histidinumsatzes wird als eine Folge der Störung des intermediären Kohlehydrat‐Stoffwechsels betrachtet. Eiweissarme oder fettfreie Diät ist ohne Einfluss auf den Histidinabbau in vivo. Desgleichen Vitamin E‐Mangel.

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Versuche zur Reinigung der Histidase

Morel

1946

Helvetica Chimica Acta

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Zur Kenntnis des intermediären Stoffwechsels des Histidins Trennung von Histidase und Urocaninase. 6. Mitteilung

Cited by 10 publications

References 0 publications

The Metabolism of Proteins and Amino Acids

The Metabolism of Proteins and Amino Acids

Die Beeinflussung des Histidinstoffwechsels durch Vitaminmangel und verschiedene Ernährungsweise

Versuche zur Reinigung der Histidase

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