Zur Kenntnis des im Harn auftretenden Porphyrins bei Bleivergiftung.

The Metabolism of Blood Pigments in Pernicious Anemia

“…For example, in certain cases of aplastic anemia (11), in certain types of cirrhosis of the liver (12), and in lead poisoning (13,14) an excretion of Type III coproporphyrin, an abnormal product, takes place.…”

The Excretion of Porphyrin in Refractory and Aplastic Anemia

“…In a second group, however, a qualitative as well as a quantitative deviation from the normal metabolism of pigments exists. The anemia of lead (6,7,8) and salvarsan poisoning (9), and of certain hepatic cirrhoses, notably hemachromatosis, are of this type (1,10).…”

Concerning the Naturally Occurring Porphyrins. Iv. The Urinary Porphyrin in Lead Poisoning as Contrasted With That Excreted Normally and in Other Diseases 1

“…The occurrence of coproporphyrin I rather than III constituted evidence that at least in the instances studied, porphyrin formation was a process distinctly separate from the synthesis or destruction of hemoglobin. The isolation of coproporphyrin III from the urine in lead poisoning was described by Grotepass (9), later by H. Fischer and Duesberg (10). Since ordinary hemin and coproporphyrin III both correspond in configuration to aetioporphyrin III, the elaboration of coproporphyrin III in lead poisoning could be associated quite readily with a peculiar disturbance in hemoglobin metabolism.…”