The Excretion of Porphyrin in Refractory and Aplastic Anemia

Dobriner, Konrad; Rhoads, C. P.; L, Hummel

doi:10.1172/jci100935

Cited by 20 publications

(4 citation statements)

References 13 publications

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“…(25,26). From these studies, together with those previously reported, it appears that the disturbance of porphyrin metabolism which characterizes congenital porphyria is quite unlike that seen in pernicious anemia (23), in pellagra (27), or in refractory anemia (28 …”

Section: Discussionsupporting

confidence: 67%

The Excretion of Porphyrins in Congenital Porphyria

Dobriner¹,

Strain²,

Guild³

et al. 1938

J. Clin. Invest.

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Section: Discussionsupporting

confidence: 67%

The Excretion of Porphyrins in Congenital Porphyria

Dobriner¹,

Strain²,

Guild³

et al. 1938

J. Clin. Invest.

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“…Nine [7,25] of these were obviously unacceptable from the viewpoint of the above criteria and the other eighteen cases [1,2,8,18,20,28,35,38,43,50,53,58,60,66] did not have the adequate descriptions on the hematological data including bone marrow findings. Nine [7,25] of these were obviously unacceptable from the viewpoint of the above criteria and the other eighteen cases [1,2,8,18,20,28,35,38,43,50,53,58,60,66] did not have the adequate descriptions on the hematological data including bone marrow findings.…”

Section: Resultsmentioning

confidence: 99%

Prognostic aspects of aplastic anemia in pregnancy

Suda

Omine

Tsuchiya

et al. 1978

Blut

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Our resent experience on six cases of aplastic anemia complicated with pregnancy is described. In addition, 43 similar cases were collected from the literature and reviewed to analyze some prognostic aspects of this relatively rare but potentially serious complication. Clinical and hematological data were treated to extract some clinically meaningful factors in relation to the success and failure of pregnancy. Among initial hematological parameters, no significant difference was found between successful and unsuccessful cases with an exception of hemoglobin concentration. The patients diagnosed as aplastic anemia prior to conception demonstrated an better outcome of pregnancy as well as survival rate of mother when compared with those diagnosed during pregnancy. Mortality has apparently improved after the late 1950's. Success rate of pregnancy before 1958 was 21%, while it was 67% and 71% in the era of 1959-1969 and after 1970, respectively. However, hemorrhage and infection remained to be two major causes of maternal death in both eras. Based on these observations, the currently recommendable attitude to this complication is discussed.

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“…In approximately one third of the cases presenting during pregnancy, an improvement in blood counts occurs after termination of pregnancy (3,4,5,7,12). In addition a small number of cases have been reported of bone marrow hypoplasia remitting with delivery and recurring during subsequent pregnancies (3,13,14), suggesting that the pregnancy has contributed to the development of aplastic anemia. On the other hand, some authors have considered the association of pregnancy with aplastic anemia to be a mere coincidence (15).…”

Section: Discussionmentioning

confidence: 99%

Pregnancy‐associated aplastic anemia ‐Report of 3 cases

Besien

Tricot

Golichowski

et al. 1991

European J of Haematology

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Pregnancy-associated aplastic anemia -Report of 3 cases. Eur J Haematol 1991: 47: 253-256. Abstract: 3 patients with pregnancy-associated aplastic anemia are reported. Management throughout most of the pregnancy consisted of supportive care. In 2 patients an improvement in blood counts occurred after delivery and, in 1 of these, the pancytopenia recurred during a subsequent pregnancy. In 1 case no improvement occurred after delivery and the patient ultimately required an allogeneic bone marrow transplantation. The outcome of these 3 cases demonstrates that pregnancy-associated aplastic anemia can be managed successfully. The improvement that often occurs after delivery suggests a pathogenetic role for pregnancy in the development of this disease.

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The Excretion of Porphyrin in Refractory and Aplastic Anemia

Cited by 20 publications

References 13 publications

The Excretion of Porphyrins in Congenital Porphyria

The Excretion of Porphyrins in Congenital Porphyria

Prognostic aspects of aplastic anemia in pregnancy

Pregnancy‐associated aplastic anemia ‐Report of 3 cases

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