Zur Kenntnis der Tetrahydrocarbolin‐Verbindungen (I. Mitteil.)

Abstract

H o r l e i n r .. , I .<63Der Versuch, die Komponenten in alkohol. Losung rniteinander reagieren zu assen und die gebildete Bromwasserstoffsaure mit N8triumhydrogencarbonat anstatt mit dem oben angewendeten iiherschiiss. Anilin zu binden, fuhrte ausschliel3lich zu Harzen. Selbst wiederholte Chromatographie der einzelnen Zonen lieferte keinen kristallisierten stoff.-L -L L ' ' " --, -~c , J C ' ~~ Nr. 4/1954]

γ-Carbolines and their hydrogenated derivatives 3.* Hydrogenated derivatives of γ-carbolines: chemical and biological poperties (Review)

“…For example, 5-(pyridylalkyl)tetrahydro-γ-carbolines (including Dimebon 2 and Dorastine 3, drugs used in medical practise) and certain other γ-carboline derivatives (e.g., Diazoline 1) have antihistamine [92][93][94][95][96][97] and antianaphylactic [20] properties. Apart from everything else, among the 5-(pyridylethyl)tetrahydro-γ-carbolines there are examples of analgesics, e.g., 4-pyridylethyl-1,2,3,4-tetrahydro-γ-carbolines [98].…”

γ-Carbolines and their hydrogenated derivatives. 2.* Hydrogenated derivatives of γ-carbolines: methods of synthesis (review)

“…For example, this is how the synthesis of 5-benzyl-2-methyl-1,2,3,4-tetrahydro-γ-carboline -the active principle of the antihistamine product Mebhydrolin (Diazolin) 15 -was achieved [58]. The use of hydrazine and piperidine hydrochlorides with 10% H 2 SO 4 as cyclization agent reduces the yield to 31% [34].…”

Synthesis and Biological Evaluation of Novel 5,8‐Disubstituted‐2‐methyl‐2,3,4,5‐tetrahydro‐1H‐pyrido[4,3‐b] indoles as 5‐HT6 and H1 Receptors Antagonists

“…During the last few years, the wide therapeutic potential of 2,3,4,5-tetrahydro-c-carbolines (2,3,4,5-tetrahydro-1H-pyrido [4,3-b]indoles) and their bio-isosteric analogs have been attracting increasing attention among researchers [1][2][3][4][5][6][7][8][9][10][11]. Thus, in the 1950s and '60s it was clearly shown that 2,3,4,5-tetrahydro-c-carbolines can be reasonably regarded as promising antihistaminic [1,2,4] and local anesthetic agents [5] as well as serotonin-release inhibitors [6].…”

“…Thus, in the 1950s and '60s it was clearly shown that 2,3,4,5-tetrahydro-c-carbolines can be reasonably regarded as promising antihistaminic [1,2,4] and local anesthetic agents [5] as well as serotonin-release inhibitors [6]. They have also been shown to possess antidepressant [7] and anti-inflammatory [4,8] activity.…”