Zur Kenntnis der Ghamrawy‐Reaktion auf Haschisch und Marihuana

Kovar, Karl‐Artur; Keilwagen, Sibylle

doi:10.1002/ardp.19843170814

Cited by 2 publications

(2 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The cause of this improvement lies in the acid-catalyzed ring opening at the cyclohexyl ether, placing a permanent positive charge on THC. This process is a precursor step in the Ghamrawy reaction. , …”

Section: Results and Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Paper Spray and Extraction Spray Mass Spectrometry for the Direct and Simultaneous Quantification of Eight Drugs of Abuse in Whole Blood

et al. 2014

View full text Add to dashboard Cite

Determination of eight drugs of abuse in blood has been performed using paper spray or extraction spray mass spectrometry in under 2 min with minimal sample preparation. A method has been optimized for quantification of amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxy-N-methylamphetamine (MDMA), 3,4-methylenedioxy-N-ethylamphetamine (MDEA), morphine, cocaine, and Δ9-tetrahydrocannabinol (THC) from a single blood spot. Sample to sample variations of 1-5% relative standard deviation were achieved using stable isotope-labeled internal standards and tandem mass spectrometry. Limits of detection for all drugs were below typical physiological and toxicological levels. Paper spray and extraction spray each used less than 10 μL of whole blood. These methods exhibit the potential for performing rapid and high-throughput assays for selective on-site multicompound quantitative screening of illicit drugs.

show abstract

Section: Results and Discussionmentioning

confidence: 99%

“…This process is a precursor step in the Ghamrawy reaction. 34,35 The best solution for morphine was to use hydroxylamine as a solvent modifier. Although the mechanism is not entirely understood, we believe hydroxylamine to be a very mild source of protons without requiring adjustment of the solution pH.…”

Section: ■ Results and Discussionmentioning

confidence: 99%