Zur Frage der Umwandlung haematogener Monozyten zu Fibroblasten in heilenden Wunden

Krupp, Serge

doi:10.1007/bf01851593

Cited by 7 publications

(1 citation statement)

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“…In the case of fibroblasts, the concept of local origin has been well supported in recent years by animal experiments using serial microscopy (3) augmented by radionuclide labelling (4), selective X-irradiation (5) and parabiosis (6). However, there is n o general agreement, for some workers claim that wound fibroblasts may be derived from macrophages or monocytes (7)(8)(9)(10). To reconcile these divergent views, Khruschov (1 1) has proposed the existence of two populations of fibroblast: shortlived 'trophic' cells of bone marrow lineage and longlived 'supportive' cells of local derivation.…”

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The wound fibroblast and macrophage. II: Their origin studied in a human after bone marrow transplantation

Stewart

Duley

Dewdney

et al. 1981

British Journal of Surgery

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The origin of the wound fibroblast and macrophage was studied in a patient following bone marrow transplantation, using sex chromosome markers. Fibroblast-like cells emigrating from explants of a 5-day-old skin wound had the host karyotype, whereas macrophages had donor markers. These results suggest that the wound fibroblast in man is of local tissue origin, whereas wound macrophages are derived from haemopoietic tissue.

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The wound fibroblast and macrophage. II: Their origin studied in a human after bone marrow transplantation

Stewart

Duley

Dewdney

et al. 1981

British Journal of Surgery

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Treatment of thoracic radionecrosis with lower rectus musculocutaneous flaps

Krupp

Guignard

1984

Chir Plastica

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Organisation of experimental thrombosis by blood cells

Feigl¹,

Susani²,

Walter

et al. 1985

Vichows Archiv A Pathol Anat

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To clarify whether thrombus organisation was carried out by local cell activity or by elements of the circulating blood we developed an artificial prosthesis, made of an impermeable polyurethane material with an athrombogenic surface but with a central part consisting of a DACRON velour ring which was thrombogenic. We implanted these devices into the aorta of 10 sheep. In these animals, organisation of the central thrombus by local aortic cells could be excluded. After varying periods of time (2-84 days), the device was removed and the organized thrombus investigated by light and electron microscopy. From our investigations the organisation process with the development of mesenchymal cellular elements proceeded in 3 steps: The activation of the mononuclear macrophage system, the appearance of myofibroblastic cells and endothelial formation. The activation of the mononuclear macrophage system is probably induced by chemospecific products of metabolism arising from aging thrombotic material. Apart from mononuclear elements such as monocytes, macrophages, and giant cells we observed fibroblast-like and myofibroblast-like cells. The matrix contained collagen. Endothelium developed on the surface of the organizing thrombus. The final stage was characterized by the formation of a pseudovessel wall, which followed the pattern of the vascular model. Our findings support the hypothesis that a thrombus may be organized by cells derived from the circulating blood.

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Zur Frage der Umwandlung haematogener Monozyten zu Fibroblasten in heilenden Wunden

Cited by 7 publications

References 97 publications

The wound fibroblast and macrophage. II: Their origin studied in a human after bone marrow transplantation

The wound fibroblast and macrophage. II: Their origin studied in a human after bone marrow transplantation

Treatment of thoracic radionecrosis with lower rectus musculocutaneous flaps

Organisation of experimental thrombosis by blood cells

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