Zur Constitution des Anthranils

Friedländer, Paul; Wleügel, S.

doi:10.1002/cber.188301602135

Cited by 22 publications

(1 citation statement)

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“…Isatoic anhydride (2 H 3,1–benzoxacin-2,4 (1 H )-dione, ISA) is a special compound in organic synthesis, first discovered by Friedländer and Wleügel [1] due to its physicochemical properties and special reactivity features which have been very well exploited in the recent past. Its tremendous importance can be exemplified by the presence of a great number of research papers and patents in the chemical literature, especially in the industrial field where it has been applied for manufacturing agrochemicals, desiccants, paints, fragrances and drug products [2,3].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Biological Evaluation of 2-Aminobenzamide Derivatives as Antimicrobial Agents: Opening/Closing Pharmacophore Site

Mabkhot

Al‐Majid

Barakat

et al. 2014

IJMS

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A series of new 2-aminobenzamide derivatives (1–10) has been synthesized in good to excellent yields by adopting both conventional and/or a time-efficient microwave assisted methodologies starting from isatoic anhydride (ISA) and characterized on the basis of their physical, spectral and microanalytical data. Selected compounds of this series were then tested against various bacterial (Bacillus subtilis (RCMB 000107) and Staphylococcus aureus (RCMB 000106). Pseudomonas aeruginosa (RCMB 000102) and Escherichia coli (RCMB 000103) and fungal strains (Saccharomyces cerevisiae (RCMB 006002), Aspergillus fumigatus (RCMB 002003) and Candida albicans (RCMB 005002) to explore their potential as antimicrobial agents. Compound 5 was found to be the most active compound among those tested, which showed excellent antifungal activity against Aspergillus fumigatus (RCMB 002003) more potent than standard Clotrimazole, and moderate to good antibacterial and antifungal activity against most of the other strains of bacteria and fungi. Furthermore, potential pharmacophore sites were identified and their activity was related with the structures in the solution.

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Section: Introductionmentioning

confidence: 99%