Zur Biochemie und Klinik der alkoholischen Leberschädigung

Abstract

Alcoholism is the most common form of drug abuse and alcoholic liver disease is a major health problem which in terms of increasing incidence is only rivaled by viral hepatitis. Cirrhosis of the liver, most of which is probably alcoholic, is among the leading causes of morbidity and mortality between the ages of 25 to 65 in Western countries. Alcoholic liver disease includes adaptive and toxic ultrastructural alterations, alcoholic fatty liver, alcoholic hepatitis and alcoholic cirrhosis, later accompanied by hepatoma.

The β-Carbolines (Harmanes) - A New Class of Endogenous Compounds:

“…Ingestion of ethyl alcohol leads to changes in the metabolic state of the organism which is dependent on dosage. In order for these metabolic processes to take place the organism requires certain coenzymes, particularly nicotinamide dinueleotide (NAD) which are then no longer available in sufficient quantities for other reactions (14,31,74). Under such circumstances the concentration of acetaldehyde as weil as the concentration of the aldehyde of dopamine and noradrenaline, serotonin and tryptarnine, could rise.…”

Bedeutung des Alkohols in der Embryofetalperiode und beim Neugeborenen

“…Sie beschreiben in der Entwicklun.g des ADH-Isoenzymmusters nur eine elektrophoretische Bande beim Feten gegentiber vier Banden beim Erwachsenen.Bei einem Neugeborenen mit Alkoholembryopathie, welches yon der Mutter im Rausch geboren wurde, landEisenburg (1977) eine Alkoholkonzentration von 1,5%0 im Nabelvenenblut. Embryonalmonat extrem niedrig und liegt auch in der Fetalperiode unter 10% der Erwachsenenrate.…”